Varicocele and male infertility: Part II - Pathophysiology of varicoceles in male infertility
Varicocele and male infertility: Part II - Pathophysiology of varicoceles in male infertility
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DOI：
10.1093/humupd/7.5.473
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发表时间：
2001-09-01
影响因子：
13.3
通讯作者：
Agarwal, A
中科院分区：
文献类型：
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作者：
Naughton, CK;Nangia, AK;Agarwal, A
精索静脉曲张在19%至41%的不育男性中发现，并且是男性不育的一种可治疗形式。精索静脉曲张对男性不育和精子发生的不同影响的机制仍不清楚。由于精索静脉曲张的突发性和多变的医源性以及研究的持续时间，实验动物模型发挥了有用的（但有限的）作用。大部分的人类数据是通过描述患有和不患有精索静脉曲张的男性之间可测量参数的相关差异而得出的。高温，睾丸血流量和静脉压的变化，反流的肾/肾上腺产品，激素功能障碍，自身免疫，顶体反应缺陷和氧化应激，精索静脉曲张的病理生理学的作用将进行讨论。
Varicoceles are found in 19 to 41% of infertile men, and is one treatable form of male infertility. The mechanism by which varicoceles cause the variable effect on male infertility and spermatogenesis is still unknown. Experimental animal models play a useful (but limited) role due to the sudden and variable iatrogenic nature of the varicoceles and the duration of the studies. Much of the human data are derived by the characterization of associated differences in measurable parameters between men with and without varicoceles. The role of hyperthermia, testicular blood flow and venous pressure changes, reflux of renal/adrenal products, hormonal dysfunction, autoimmunity, defects in acrosome reaction, and oxidative stress, in the pathophysiology of varicocele will be discussed.