Staphylococcus aureus infections in children.
Staphylococcus aureus infections in children.
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DOI：
10.1097/qco.0000000000000752
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发表时间：
2021-10-01
影响因子：
3.9
通讯作者：
Thomsen I
中科院分区：
文献类型：
--
作者：
Cassat JE;Thomsen I
金黄色葡萄球菌是美国和世界许多地区感染儿童的最常见的侵入性细菌病原体。这一主要的人类病原体继续演变，认识流行病学、治疗学和未来视野的最新趋势非常重要。在过去的十年中，甲氧西林敏感的S。金黄色葡萄球菌（MSSA）的发生，使得耐甲氧西林的S.金黄色葡萄球菌（MRSA）不再主导侵袭性疾病的景观。然而，抗生素耐药性继续发展，迫切需要新的治疗或预防方法。不幸的是，最近的几次疫苗尝试在人类身上都没有成功。最近的科学突破突出了针对S.金黄色葡萄球菌通过干扰毒力，而不是通过传统的抗菌机制。色葡萄金黄色葡萄球菌疫苗仍然难以捉摸;造成这种情况的原因是多方面的，从以前不成功的尝试中吸取的教训可能会为有效的预防开辟一条道路。最后，新的诊断模式有可能大大提高侵袭性链球菌的临床护理。儿童金黄色葡萄球菌病。
Staphylococcus aureus is the most common invasive bacterial pathogen infecting children in the U.S. and many parts of the world. This major human pathogen continues to evolve, and recognition of recent trends in epidemiology, therapeutics and future horizons is of high importance. Over the past decade, a relative rise of methicillin-susceptible S. aureus (MSSA) has occurred, such that methicillin-resistant S. aureus (MRSA) no longer dominates the landscape of invasive disease. Antimicrobial resistance continues to develop, however, and novel therapeutics or preventive modalities are urgently needed. Unfortunately, several recent vaccine attempts proved unsuccessful in humans. Recent scientific breakthroughs highlight the opportunity for novel interventions against S. aureus by interfering with virulence rather than by traditional antimicrobial mechanisms. A S. aureus vaccine remains elusive; the reasons for this are multifactorial, and lessons learned from prior unsuccessful attempts may create a path toward an effective preventive. Finally, new diagnostic modalities have the potential to greatly enhance clinical care for invasive S. aureus disease in children.