Release of fascial compartment boundaries reduces muscle force output.
Release of fascial compartment boundaries reduces muscle force output.
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筋膜室边界的释放减少了肌肉力量的输出。
DOI：
10.1152/japplphysiol.00330.2018
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Roberts,ThomasJ
中科院分区：
文献类型：
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作者：
Ruttiman,RoyJ;Sleboda,DavidA;Roberts,ThomasJ
大多数肢体肌肉在由筋膜层限定的隔室内运作，筋膜层将肌肉或肌肉群包围在限定的空间内。这些隔室在临床上是重要的，因为如果不治疗，液体积聚可引起缺血和组织坏死。然而，人们对筋膜外壳如何影响健康的肌肉功能知之甚少。先前的一项研究表明，去除筋膜覆盖物会减少肌肉在最大刺激下的力量输出。我们假设这种力输出的减少是由于筋膜切开术后肌肉长度的变化，并且可以通过肌肉的长度-张力关系来解释力输出的减少。因此，我们预测筋膜切开术后，不同长度范围内的最大力将保持不变。我们测量了最大强直性肌力输出在野生火鸡的翅膀肌肉之前和之后的筋膜，封闭的肌肉在一个隔间。我们的假设没有得到支持。该肌肉的长度-张力曲线显示，去除筋膜将最大力输出降低至筋膜前释放条件的72 ± 10%。因此，筋膜切开术后肌肉力量的减少不能用肌肉长度的变化来解释。力量减少的机制尚不清楚，但它表明，大多数孤立肌肉实验的假设，即，肌肉从其在体内的位置移除并不影响其最大机械输出，可能需要重新检查。新&值得注意的是大多数肢体肌肉被封闭在由坚固的筋膜片约束的隔室中。肌肉和筋膜紧密堆积的机械意义在很大程度上尚未被探索。我们使用动物模型来证明去除筋膜覆盖物会降低收缩过程中产生的最大力。这些结果提出了关于使用孤立的肌肉来估计肌肉性能的问题，并表明肌肉的机械环境通过尚不清楚的机制影响性能。
Most limb muscles operate within a compartment defined by fascial layers that enclose a muscle or groups of muscles within a defined space. These compartments are important clinically, because fluid accumulation can cause ischemia and tissue necrosis if untreated. Little is known, however, about how fascial enclosures influence healthy muscle function. One previous study showed that removing a fascial covering reduced the force output of a muscle under maximal stimulation. We hypothesized that such reduction in force output was due to a change in the muscle length following fasciotomy and that a reduced force output could be explained by the length-tension relationship of muscle. Thus we predicted that the maximum force across a range of lengths would be unchanged following fasciotomy. We measured maximal tetanic force output in a wing muscle in wild turkeys both before and after removal of fascia that enclosed the muscle in a compartment. Our hypothesis was not supported. The length-tension curve of this muscle showed that removal of fascia reduced maximum force output to 72 ± 10% of the prefascial release condition. Thus a reduction in muscle force following fasciotomy was not explained by a change in muscle length. The mechanism underlying reduction in force is unclear, but it suggests that the assumption underlying most isolated muscle experiments, i.e., removal of a muscle from its situation in vivo does not influence its maximal mechanical output, may need reexamining.NEW & NOTEWORTHYMost limb muscles are enclosed within compartments bound by robust fascial sheets. The mechanical significance of the close packing of muscle and fascia is largely unexplored. We used an animal model to show that removal of a fascial covering reduces the maximal force developed during contraction. These results raise questions about the use of isolated muscles to estimate muscle performance and suggest that a muscle's mechanical surrounding influences performance by mechanisms that are not understood.