Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma
Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma
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DOI：
10.1002/cncr.21159
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发表时间：
2005-07-15
期刊：
影响因子：
6.2
通讯作者：
Hatakeyama, K
中科院分区：
文献类型：
--
作者：
Cruz, PV;Wakai, T;Hatakeyama, K
背景癌胚抗原相关细胞粘附分子I（CEACAM 1）是肿瘤细胞生长的负调节因子，可能具有肿瘤抑制作用。在许多恶性肿瘤中，CEACAM 1表达随着组织学分级的增加而下调。作者推测CEACAM 1在肝细胞癌（HCC）细胞中表达的缺失可能是一个不良预后因素。对139例接受HCC切除术的连续患者进行了回顾性分析，中位随访期为83个月。使用单克隆抗CEACAM 1抗体进行切除标本的免疫组织化学。CEACAMI在HCC中的表达分为两类：弥漫性表达，其特征在于在整个肿瘤标本中的阳性染色，或表达缺失，其中在肿瘤细胞内存在明显的阴性染色区域。在139名患者中，113名被归类为具有弥漫性表达的肿瘤，26名具有表达缺失的肿瘤。CEACAMI表达缺失在Edmondson-Steiner分级为III或IV的肿瘤标本中（21/32 [66%]）比I或II级的肿瘤标本（5/107 [5%]; P < 0.001）更常见，并且总是在组织学分级最高的区域观察到。根据单变量（P < 0.0001）和多变量分析（相对危险度，5.737; P <0.001），CEAGAM 1表达缺失与肿瘤大小、肿瘤多样性、门静脉侵犯和卫星结节显著相关，并对生存率产生不利影响。CEACAMI表达的缺失反映了侵袭性肿瘤生物学，因此表明HCC患者的预后不良。(c)2005年美国癌症协会。
BACKGROUND. Carcinoembryonic antigen-related cell adhesion molecule I (CEACAM1 ) is a negative regulator of tumor cell growth, and may function as a tumor suppressor. CEACAM1 expression is down-regulated with increasing histologic grade in a number of malignancies. The authors hypothesized that loss of CEACAM1 expression in hepatocelfular carcinoma (HCC) cells may function as an adverse prognostic factor.METHODS. A retrospective analysis was conducted of 139 consecutive patients who underwent resection for HCC, with a median follow-up period of 83 months. Immunohistochemistry of the resected specimens was conducted using a monoclonal anti-CEACAM1 antibody. CEACAMI expression in HCC was classified into two categories: diffuse expression, characterized by positive staining throughout the tumor specimen, or loss of expression, in which there were distinct areas of negative staining within the tumor specimen.RESULTS. Of the 139 patients, 113 were classified as having tumors with diffuse expression and 26 had loss-of-expression tumors. Loss of CEACAMI expression was more frequent in tumor specimens with Edmondson-Steiner Grades III or IV (21 of 32 [66%]) than in tumor specimens with Grades I or II (5 of 107 [5%]; P < 0.001) and was always seen in areas with the highest histologic grade. Loss of CEAGAM1 expression was significantly associated with large tumor size, multiplicity of the tumor, portal vein invasion, and satellite nodules and affected survival adversely, according to univariate (P < 0.0001) and multivariate analyses (relative risk, 5.737; P < 0.001).CONCLUSIONS. Loss of CEACAMI expression reflects aggressive tumor biology and thus indicates a poor prognosis for patients with HCC. (c) 2005 American Cancer Society.