Population genetics of polymorphism and divergence in rapidly evolving populations
Population genetics of polymorphism and divergence in rapidly evolving populations
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快速进化群体中多态性和分化的群体遗传学
DOI：
10.1093/genetics/iyac053
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发表时间：
2022
期刊：
影响因子：
3.3
通讯作者：
Desai, Michael M
中科院分区：
文献类型：
--
作者：
Melissa, Matthew J;Good, Benjamin H;Fisher, Daniel S;Desai, Michael M
在快速进化的种群中，许多有益和有害的突变可以同时出现并在种群中分离。在这种制度下，进化动力学不能使用传统的人口遗传学方法，假设网站独立进化进行分析。相反，必须同时分析许多位点的动态。最近的工作取得了进展，首先分析了人口内的健身变化，然后研究个人血统如何与这种旅行健身波相互作用。然而，这些“行波”模型以前被限制在极端的情况下，选择个别突变要么快得多，要么慢得多，比典型的合并时间尺度Tc。在这项工作中，我们展示了如何行波框架可以扩展到中间政权中的缩放健身效果的突变（TCS）是既不大也不小相比。这使我们能够描述种群的动态受到广泛的健身效果，特别是在情况下，它不是立即清楚哪些突变是最重要的，在塑造的动态和统计的遗传多样性。我们使用这种方法来获得新的表达式的固定概率和站点频谱的突变作为其缩放健身效果的函数，沿着与相关结果的合并timescale Tc和适应或穆勒棘轮的速率。我们发现，连锁突变之间的竞争可能会对中性和选择性多态性的比例产生巨大影响，这并不是简单地用比例选择系数来概括的。最后，我们讨论了这些结果对人口遗传推断的影响。
In rapidly evolving populations, numerous beneficial and deleterious mutations can arise and segregate within a population at the same time. In this regime, evolutionary dynamics cannot be analyzed using traditional population genetic approaches that assume that sites evolve independently. Instead, the dynamics of many loci must be analyzed simultaneously. Recent work has made progress by first analyzing the fitness variation within a population, and then studying how individual lineages interact with this traveling fitness wave. However, these “traveling wave” models have previously been restricted to extreme cases where selection on individual mutations is either much faster or much slower than the typical coalescent timescaleTc. In this work, we show how the traveling wave framework can be extended to intermediate regimes in which the scaled fitness effects of mutations (Tcs) are neither large nor small compared to one. This enables us to describe the dynamics of populations subject to a wide range of fitness effects, and in particular, in cases where it is not immediately clear which mutations are most important in shaping the dynamics and statistics of genetic diversity. We use this approach to derive new expressions for the fixation probabilities and site frequency spectra of mutations as a function of their scaled fitness effects, along with related results for the coalescent timescaleTcand the rate of adaptation or Muller’s ratchet. We find that competition between linked mutations can have a dramatic impact on the proportions of neutral and selected polymorphisms, which is not simply summarized by the scaled selection coefficient. We conclude by discussing the implications of these results for population genetic inferences.
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影响因子：
3.3
作者：
S. Sawyer;D. Hartl
通讯作者：
S. Sawyer;D. Hartl
影响因子：
1.5
作者：
Nachman, MW
通讯作者：
Nachman, MW
影响因子：
1.4
作者：
Barton, N. H.;Etheridge, A. M.;Veber, A.
通讯作者：
Veber, A.
当突变具有广泛的有害影响时，突变干扰和穆勒棘轮的进展
影响因子：
3.3
作者：
R. Söderberg;O. Berg
通讯作者：
O. Berg
DOI：
10.1073/pnas.1702314114
发表时间：
2017-08-01
影响因子：
11.1
作者：
Buskirk, Sean W.;Peace, Ryan Emily;Lang, Gregory I.
通讯作者：
Lang, Gregory I.