Polychlorinated androstanes from the burrowing sponge Cliona nigricans
Polychlorinated androstanes from the burrowing sponge Cliona nigricans
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DOI：
10.1021/ol049548r
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发表时间：
2004-05-13
期刊：
影响因子：
5.2
通讯作者：
Ianaro, A
中科院分区：
文献类型：
--
作者：
Fattorusso, E;Taglialatela-Scafati, O;Ianaro, A
已经从挖洞的海绵克利昂娜·尼古拉（Cliona Nigricans）中分离出了两个新的类固醇衍生物，称为Clionastatins A和B。这些分子分别是三氯化雄激素衍生物，它们代表了在天然生物体中发现的第一个多面化类固醇，无论是海洋还是陆地，也是自然界中卤代雄激素的第一个例子。事实证明，这两种clionastatin都具有有效的细胞毒性。
Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetrachlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic.