Stimulation of the nucleus raphe obscurus produces marked serotonin release into the dorsal medulla of fed but not fasted rats--glutamatergic dependence.
Stimulation of the nucleus raphe obscurus produces marked serotonin release into the dorsal medulla of fed but not fasted rats--glutamatergic dependence.
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刺激中缝暗核会产生显着的血清素释放到进食但未禁食的大鼠的背髓质中——谷氨酸能依赖性。
DOI：
10.1016/0006-8993(95)00505-k
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发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
StephensJr,RL
中科院分区：
文献类型：
--
作者：
Mohammed,JR;Saska,TA;Chi,J;StephensJr,RL
血清素与背侧迷走神经复合体 (DVC) 处的 TRH 相互作用，以增强胃功能参数。为了确定生理相关性，对末端场的刺激释放模式进行了表征。红藻氨酸 (423 pmol/10 nl) 刺激中缝暗核 (nRO) 会在自由喂养但 24 小时禁食的大鼠中将血清素显着释放到含有 DVC 的背髓透析液中。探针输注犬尿酸 (1 mM)，但不是急性双侧颈部迷走神经切断术，可减弱饲喂动物中 nRO 刺激的血清素释放。结果表明，进食状态通过背髓质中兴奋性氨基酸受体激活介导的机制促进血清素释放到背髓质中。 DVC 处增强的血清素能神经传递可能包含迄今为止未识别的对膳食的综合迷走神经反应的组成部分。
Serotonin interacts with TRH at the dorsal vagal complex (DVC) to augment gastric functional parameters. To ascertain physiologic relevance, patterns of stimulated release at the terminal field were characterized. Stimulation of the nucleus raphe obscurus (nRO) by kainic acid (423 pmol/10 nl) produced marked release of serotonin into dorsal medullary dialysates containing the DVC in freely fed, but not 24-h fasted rats. Probe infusion of kynurenic acid (1 mM), but not acute bilateral cervical vagotomy attenuated nRO-stimulated serotonin release in fed animals. The results suggest that the fed state facilitates serotonin release into the dorsal medulla by a mechanism mediated by activation of excitatory amino acid receptors in the dorsal medulla. Enhanced serotonergic neurotransmission at the DVC may comprise a heretofore unrecognized component of the integrated vago-vagal response to a meal.