Role of granuloma in the immunopathogenesis of Crohn's disease
Role of granuloma in the immunopathogenesis of Crohn's disease
复制标题
DOI：
10.1159/000051910
复制
发表时间：
2001-01-01
期刊：
影响因子：
3.2
通讯作者：
Nagura, H
中科院分区：
文献类型：
--
作者：
Matsumoto, T;Nakamura, S;Nagura, H
炎症性肠病（溃疡性结肠炎和克罗恩病）是病因不明的慢性持久炎症性疾病。近年来的研究表明，这两种疾病都与遗传易感性和环境因素如肠道微生物和抗原有关。克罗恩病与组织病理学特征如肉芽肿形成和纵向溃疡有关。在这篇文章中，我们描述了肉芽肿在克罗恩病的免疫发病机制中的作用。克罗恩病肉芽肿可能作为记忆型T细胞的抗原提呈位点，导致T细胞的活化和增殖。肉芽肿中的抗原可能与疾病密切相关。版权所有（C）2001 S. Karger AG，巴塞尔。
Inflammatory bowel diseases (ulcerative colitis and Crohn's disease) are chronic long-lasting inflammatory diseases with yet unknown etiology. Recent advancement revealed that both diseases are associated with genetic predisposition and environmental factors such as luminal microorganisms and antigens. Crohn's disease is associated with histopathologic features such as granuloma formation and longitudinal ulceration. In this article we describe the role of granuloma in the immunopathogenesis of Crohn's disease. Granuloma of Crohn's disease may play crucial roles as antigen-presenting cites to memory type T cells, which leads to activation and proliferation of T cells. Antigens presented at granuloma may be closely related to the disease. Copyright (C) 2001 S. Karger AG, Basel.