Integrating fMRI and single-cell data of visual working memory
Integrating fMRI and single-cell data of visual working memory
复制标题
整合功能磁共振成像和视觉工作记忆的单细胞数据
DOI：
10.1016/j.neucom.2004.01.120
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发表时间：
2004
期刊：
影响因子：
6
通讯作者：
B. Horwitz
中科院分区：
文献类型：
--
作者：
G. Deco;E. Rolls;B. Horwitz
基于单细胞和功能磁共振成像数据，目前提出了两种不同的前额皮质拓扑和功能组织模型：刺激域组织模型和过程组织模型。目前的工作利用基于计算神经科学的方法，通过详细的大规模微观神经动力学计算模型，整合与工作记忆处理相关的前额皮质（PFC）的单细胞和功能磁共振成像测量，以深入研究 PFC 的拓扑结构问题。为此，我们制定了一个明确的尖峰和突触动力学机制模型，该模型是执行延迟任务期间工作记忆相关活动的基础，采用“什么”-“然后”-“哪里”设计（同一试验中的对象和空间延迟响应）。
Based on single-cell and fMRI data, two different current models of the topographical and functional organization of the prefrontal cortex has been proposed: organization-by-stimulus-domain model, and organization-by-process model. The present work utilizes a computational neuroscience-based approach in order to integrate, via a detailed large-scale microscopic neurodynamical computational model, single-cells and fMRI measurements of the prefrontal cortex (PFC) associated with working memory processing, in order to delve into the question on the topographical structure of the PFC. For this purpose, we formulate an explicit model of the spiking and synaptic dynamical mechanisms that underly working memory-related activity during the execution of delay tasks with a ‘what’–then–‘where’ design (object and spatial delayed response within the same trial).