Early local immune defences in the respiratory tract.
Early local immune defences in the respiratory tract.
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DOI：
10.1038/nri.2016.117
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Molony RD
中科院分区：
文献类型：
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作者：
Iwasaki A;Foxman EF;Molony RD
呼吸道免疫反应由多层细胞反应组成，这些细胞反应以顺序的方式参与，以控制感染。随着宿主适应成本的逐步增加，效应函数的逐步参与限制了组织损伤。此外，还建立了特定机制，以促进对呼吸道感染的疾病耐受。环境因素、肥胖和衰老过程可以改变这种分层反应的效率和调节，从而增加病理和死亡率。在这篇综述中，我们描述了通过一系列细胞因子分泌来协调病原体清除和组织修复的细胞类型，并讨论了环境和合并症如何影响这种反应。
The respiratory immune response consists of multiple tiers of cellular responses that are engaged in a sequential manner in order to control infections. Stepwise engagement of effector functions with progressively increasing host fitness costs limits tissue damage. In addition, specific mechanisms are in place to promote disease tolerance in response to respiratory infections. Environmental factors, obesity and the ageing process can alter the efficiency and regulation of this tiered response, increasing pathology and mortality as a result. In this Review, we describe the cell types that coordinate pathogen clearance and tissue repair through serial secretion of cytokines, and discuss how the environment and comorbidity influence this response.