A single-cell transcriptomic atlas characterizes ageing tissues in the mouse.
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse.
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DOI：
10.1038/s41586-020-2496-1
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发表时间：
2020-07
期刊：
影响因子：
64.8
通讯作者：
Tabula Muris Consortium
中科院分区：
文献类型：
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作者：
Tabula Muris Consortium
衰老的特征是生理完整性的逐渐丧失，导致功能受损和死亡的脆弱性增加。尽管近年来进展迅速，但许多导致健康生理学逐渐丧失的分子和细胞过程仍知之甚少。为了更好地了解这些过程，我们创建了一个跨越小家鼠寿命的单细胞转录组图谱，其中包括来自23个组织和器官的数据。我们发现了发生在多种细胞类型和器官中的细胞特异性变化，以及不同器官细胞组成的年龄相关变化。使用单细胞转录组数据，我们能够评估衰老的不同标志的细胞类型特异性表现，例如衰老，基因组不稳定性和生物体免疫系统的变化。这个Tabula Muris Senis提供了大量关于衰老的最重要标志如何反映在广泛的组织和细胞类型中的新分子信息。
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes which underlie progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes we have created a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 23 tissues and organs. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence, genomic instability and changes in the organism’s immune system. This Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.