OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY
OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY
复制标题
中心性浆液性脉络膜视网膜病变的光学相干断层血管造影
DOI：
10.1097/iae.0000000000001064
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发表时间：
2016-11-01
影响因子：
3.3
通讯作者：
Jonas, Jost B.
中科院分区：
文献类型：
--
作者：
Chan, Szy Yann;Wang, Qian;Jonas, Jost B.
目的：应用光学相干断层血管造影术（OCT-血管造影），我们检查了中心性浆液性脉络膜视网膜病变（CSC）患者的脉络膜毛细血管。研究方法：前瞻性观察性临床研究包括CSC患者定义为无痛性中心视力丧失和存在浆液性黄斑脱离，如光谱域OCT所示。所有眼睛均接受OCT血管造影。测量中心凹下脉络膜厚度和脉络膜毛细血管宽度。结果：该研究包括21例患者的26只眼，平均年龄为47.0 ± 7.9岁（范围：34-65岁）。所有26只眼均显示高信号图像模式，21只眼在OCT血管造影图像中还显示毛细血管扩张。OCT血管造影显示异常的区域与荧光素血管造影中的渗漏区域或吲哚菁绿色血管造影中的高渗透性区域一致。在16例单侧CSC患者中，1例患者在对侧临床未受影响的眼睛的OCT血管造影中显示高强度模式。与单侧CSC中对侧未受影响的眼睛相比，受累眼睛的脉络膜厚度测量值较厚，OCT血管造影显示受累眼睛的脉络膜毛细血管测量值显著较厚。常规荧光素血管造影未显示渗漏的14/18眼临床诊断CSC。结论：光学相干断层血管造影显示高信号强度的所有眼睛与CSC和扩张的血管脉络膜毛细血管在大多数眼睛临床诊断CSC的图像模式。结果表明，OCT血管造影可能成为一种非侵入性的有价值的工具，特别是CSC的诊断和黄斑疾病的诊断一般。
Purpose: Using optical coherence tomographic angiography (OCT-angiography), we examined the vasculature of the choriocapillaris in patients with central serous chorioretinopathy (CSC). Methods: The prospective observational clinical study included patients with CSC defined by painless loss of central visual acuity and presence of a serous macular detachment as visualized by spectral-domain OCT. All eyes underwent OCT-angiography. Subfoveal choroidal thickness and choriocapillaris width were measured. Results: The study included 26 eyes of 21 patients with a mean age of 47.0 ± 7.9 years (range: 34–65 years). All 26 eyes showed an image pattern of high signal intensity, and 21 eyes additionally demonstrated dilated capillaries in the OCT-angio images. The areas showing abnormalities in the OCT-angiography were congruent with leaking areas in fluorescein angiography or areas with hyperpermeability in indocyanine green angiography. Among 16 patients with unilateral CSC, 1 patient showed a high intensity pattern in the OCT-angiogram in the contralateral, clinically unaffected eye. Parallel to thicker choroidal thickness measurements in affected eyes as compared with contralateral unaffected eyes in unilateral CSC, OCT-angiography revealed significantly thicker choriocapillaris measurements in the affected eyes. Conventional fluorescein angiography did not demonstrate leakage in 14 of 18 eyes with clinically diagnosed CSC. Conclusion: Optical coherence tomographic angiography showed an image pattern of high signal intensity in all eyes with CSC and dilated vessels in the choriocapillaris in most eyes with clinically diagnosed CSC. The results indicate that OCT-angiography may become a noninvasive valuable tool for the diagnosis of CSC in particular and for the diagnosis of macular disorders in general.