PREVENTIVE EFFECTS OF CYCLOSPORINE ON DIABETES IN NOD MICE
PREVENTIVE EFFECTS OF CYCLOSPORINE ON DIABETES IN NOD MICE
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DOI：
10.1007/bf00454884
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发表时间：
1986-04-01
期刊：
影响因子：
8.2
通讯作者：
IKEDA, Y
中科院分区：
文献类型：
--
作者：
MORI, Y;SUKO, M;IKEDA, Y
每2天用25、15和2.5 mg/kg剂量的环孢菌素口服治疗30至60日龄的非肥胖糖尿病小鼠，直至160日龄。在18只油处理的小鼠中有12只（67%）发生糖尿病，部分至完全的朗格汉斯胰岛破坏与淋巴细胞浸润有关。非肥胖型糖尿病小鼠显示出6.62 ± 0.01的血浆葡萄糖浓度。0.92 mmol/l（平均值±. SD）。油处理的非肥胖型糖尿病小鼠的血浆葡萄糖水平在130日龄后逐渐升高，并在160日龄时达到14.0至19.0 mmol/l，而环孢霉素处理的非肥胖型糖尿病小鼠既未显示出血浆葡萄糖水平的明显升高，也未出现胰岛炎。在葡萄糖耐受不良发生后，环孢素治疗小鼠的糖尿病累积发病率显著低于油治疗小鼠。每2天给予25 mg/kg环孢菌素，持续35天。环孢菌素似乎对非肥胖糖尿病小鼠的糖尿病几乎没有治疗作用。
Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans'' islets destruction associated with lymphocytic infiltration. The non-obese diabetic mice showed a plasma glucose concentration of 6.62 .+-. 0.92 mmol/l (mean .+-. SD) at 50 days of age. The plasma glucose level of oil-treated non-obese diabetic mice gradually increased after 130 days of age and reached 14.0 to 19.0 mmol/l at 160 days of age, while Cyclosporin-treated non-obese diabetic mice showed neither clear increase of plasma glucose levels nor development of insulitis. The cumulative incidence of diabetics in Cyclosporin-treated mice was significantly lower than that in oil-treated was started after development of glucose intolerance. Twenty-five mg/kg of Cyclosporin was administered every 2 days for 35 days. Cyclosporin appeared to have little therapeutic effect on diabetes in non-obese diabetic mice.