Synthesis, In vitro degradation, and mechanical properties of two-component poly(ester urethane)urea scaffolds:: Effects of water and polyol composition
Synthesis, In vitro degradation, and mechanical properties of two-component poly(ester urethane)urea scaffolds:: Effects of water and polyol composition
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DOI：
10.1089/ten.2006.0395
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发表时间：
2007-09-01
影响因子：
--
通讯作者：
Hollinger, Jeffrey
中科院分区：
文献类型：
--
作者：
Guelcher, Scott;Srinivasan, Abiraman;Hollinger, Jeffrey
骨科临床条件下微创治疗的发展具有实质性的益处，特别是对骨质疏松性脆性骨折和椎体压缩性骨折。聚（酯聚氨酯）尿素（PEUUR）泡沫对于解决这些问题是潜在的有用的，因为它们在注射后原位固化形成多孔支架。在本研究中，研究了水浓度和聚酯三醇组成对PEUUR泡沫的物理化学、力学和生物性能的影响。将液态树脂（赖氨酸二异氰酸酯）和硬化剂（聚（epsiln -己内酯-共乙醇酸-共dl -丙交酯）三醇、叔胺催化剂、阴离子稳定剂和脂肪酸衍生的开孔剂）混合在一起，将得到的反应液体混合物注射到模具中硬化。通过在百份多元醇0.5 ~ 2.75份的范围内改变含水量，制备了孔隙率为89.1 ~ 95.8 vol-%的材料。在播种21天后，PEUUR泡沫中的细胞开始渗透，这表明孔是开放的，并且相互连接。在体外，这些材料产生了无细胞毒性的分解产物，聚酯三醇成分半衰期的差异转化为PEUUR泡沫降解率的差异。我们预计，由于其良好的生物和物理特性，PEUUR泡沫将为设计新的组织工程支架和输送系统提供令人信服的机会。
The development of minimally invasive therapeutics for orthopedic clinical conditions has substantial benefits, especially for osteoporotic fragility fractures and vertebral compression fractures. Poly(ester urethane)urea (PEUUR) foams are potentially useful for addressing these conditions because they cure in situ upon injection to form porous scaffolds. In this study, the effects of water concentration and polyester triol composition on the physicochemical, mechanical, and biological properties of PEUUR foams were investigated. A liquid resin (lysine diisocyanate) and hardener (poly(epsilon-caprolactone-co-glycolide-co-DL-lactide) triol, tertiary amine catalyst, anionic stabilizer, and fatty acid-derived pore opener) were mixed, and the resulting reactive liquid mixture was injected into a mold to harden. By varying the water content over the range of 0.5 to 2.75 parts per hundred parts polyol, materials with porosities ranging from 89.1 to 95.8 vol-% were prepared. Cells permeated the PEUUR foams after 21 days post-seeding, implying that the pores are open and interconnected. In vitro, the materials yielded non-cytotoxic decomposition products, and differences in the half-life of the polyester triol component translated to differences in the PEUUR foam degradation rates. We anticipate that PEUUR foams will present compelling opportunities for the design of new tissue-engineered scaffolds and delivery systems because of their favorable biological and physical properties.