Mutator bacteria as a risk factor in treatment of infectious diseases
Mutator bacteria as a risk factor in treatment of infectious diseases
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DOI：
10.1128/aac.46.3.863-865.2002
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发表时间：
2002-03-01
影响因子：
4.9
通讯作者：
Taddei, F
中科院分区：
文献类型：
--
作者：
Giraud, A;Matic, I;Taddei, F
我们在灵知生鼠模型中显示，除了直接选择抗药性细菌外，一些抗生素治疗还选择突变等位基因。由于这些突变等位基因的高突变率，最初的治疗失败增加了随后使用其他药物治疗失败的可能性。
We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.