Canonical and non-canonical Hedgehog signalling and the control of metabolism.
Canonical and non-canonical Hedgehog signalling and the control of metabolism.
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DOI：
10.1016/j.semcdb.2014.05.007
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发表时间：
2014-09
影响因子：
7.3
通讯作者：
Pospisilik JA
中科院分区：
文献类型：
--
作者：
Teperino R;Aberger F;Esterbauer H;Riobo N;Pospisilik JA
肥胖和糖尿病是当今医疗保健的主要挑战，影响着全球超过10亿人。这些人患癌症、中风、失明、心脏病和心血管疾病的风险较高，迄今为止，还没有有效的长期治疗方案。最近越来越多的证据表明发育形态原Hedgehog及其下游信号在代谢控制中起作用。通常认为Hedgehog在成人中是静止的，它与几种人类癌症有关，因此已经成为肿瘤学的治疗靶点。在这里，我们试图给出一个全面的概述与规范和非规范刺猬信号相关的关键信号事件，并强调越来越复杂的监管模式，似乎连接刺猬和控制代谢。我们强调这些关键发现，并讨论其对治疗发展，癌症和代谢疾病的影响。
Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of one billion people worldwide. These individuals are at higher risk for cancer, stroke, blindness, heart and cardiovascular disease, and to date, have no effective long-term treatment options available. Recent and accumulating evidence has implicated the developmental morphogen Hedgehog and its downstream signalling in metabolic control. Generally thought to be quiescent in adults, Hedgehog is associated with several human cancers, and as such, has already emerged as a therapeutic target in oncology. Here, we attempt to give a comprehensive overview of the key signalling events associated with both canonical and non-canonical Hedgehog signalling, and highlight the increasingly complex regulatory modalities that appear to link Hedgehog and control metabolism. We highlight these key findings and discuss their impact for therapeutic development, cancer and metabolic disease.
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影响因子：
3.5
作者：
Beug, Shawn T.;Parks, Robin J.;Wallace, Valerie A.
通讯作者：
Wallace, Valerie A.
DOI：
10.1073/pnas.0705603105
发表时间：
2008-01-22
影响因子：
11.1
作者：
Callejo, Ainhoa;Culi, Joaquim;Guerrero, Isabel
通讯作者：
Guerrero, Isabel
影响因子：
20.3
作者：
Blotta, Simona;Jakubikova, Jana;Munshi, Nikhil C.
通讯作者：
Munshi, Nikhil C.
影响因子：
4.3
作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
影响因子：
7.3
作者：
Bijlsma, Maarten F.;Damhofer, Helene;Roelink, Henk
通讯作者：
Roelink, Henk