Salt-induced transition between two double-helical forms of oligo (dC-dG).

Salt-induced transition between two double-helical forms of oligo (dC-dG).
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盐诱导两个双螺旋寡核苷酸 (dC-dG) 之间的转变。

DOI:
10.1101/sqb.1983.047.01.014
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发表时间:
1983
期刊:
Cold Spring Harbor symposia on quantitative biology
影响因子:
--
通讯作者:
F. Pohl
F. Pohl
中科院分区:
--
文献类型:
--
作者:
F. Pohl

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The change between a right-handed and a left-handed double-helical structure is certainly an extreme example of the conformational variability of DNA. Studying the energetics and dynamics with defined oligomers provides a convenient way to obtain a quantitative understanding of such processes and can serve as a model for possible regulatory mechanisms in biological systems. Monoclonal antibodies with different specificities to Z-DNA offer a promising technique to search for such structures in more-complicated systems and represent a model system for the quantitative investigation of the interaction of proteins with particular conformations of DNA.