Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort.
Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort.
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DOI：
10.1186/s12889-021-11892-5
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发表时间：
2021-10-23
影响因子：
4.5
通讯作者：
Benegal V
中科院分区：
文献类型：
--
作者：
Fernandes GS;Spiers A;Vaidya N;Zhang Y;Sharma E;Holla B;Heron J;Hickman M;Murthy P;Chakrabarti A;Basu D;Subodh BN;Singh L;Singh R;Kalyanram K;Kartik K;Kumaran K;Krishnaveni G;Kuriyan R;Kurpad S;Barker GJ;Bharath RD;Desrivieres S;Purushottam M;Orfanos DP;Toledano MB;Schumann G;Benegal V
不良童年经历(ACE)增加了对物质滥用等外部性障碍的易感性。这项研究旨在确定ACE的患病率及其与药物滥用的关系。使用了印度外化障碍和成瘾脆弱性联盟的数据(n= 9010)。使用世界卫生组织(WHO)儿童不良经历国际问卷对ACE进行评估，同时使用WHO酒精、吸烟和物质参与筛查测试评估物质滥用。一项随机效应的两阶段个人患者数据荟萃分析解释了ACE与物质滥用之间的联系，并对性别和家庭结构等混杂因素进行了调整。每2名参与者中就有1名报告虐待儿童和家庭水平的A。除了性虐待，男性报告的每一个童年逆境都比女性更多，而且比女性更有可能报告滥用药物(87.3%比12.7%)。在青少年中，家庭层面的ACE(ADJ OR 4.2，95%CI 1.5-11.7)和集体层面的ACE(ADJ OR 6.6，95%CI 1.4-31.1)与药物滥用有关，而在青少年中，儿童层面的ACE(如虐待)显示出类似的强烈关联(ADJ OR 2.0，95%CI 1.1-3.5)。在印度青少年和年轻成年男性中，虐待和家庭暴力等王牌与药物滥用密切相关，最常见的是烟草。这一结果建议加强目前的ACE复原力计划和“创伤知情”方法，以应对ACE在印度的长期影响。牛顿·巴巴·格兰特由英国医学研究理事会(MR/N000390/1)和印度医学研究理事会(ICMR/MRC-UK/3/M/2015-NCD-I)共同资助。网上版载有补充材料，可在10.1186/s12889-021-11892-5查阅。
Adverse childhood experiences (ACEs) increases vulnerability to externalising disorders such as substance misuse. The study aims to determine the prevalence of ACEs and its association with substance misuse. Data from the Consortium on Vulnerability to Externalising Disorders and Addictions (cVEDA) in India was used (n = 9010). ACEs were evaluated using the World Health Organisation (WHO) Adverse Childhood Experiences International Questionnaire whilst substance misuse was assessed using the WHO Alcohol, Smoking and Substance Involvement Screening Test. A random-effects, two-stage individual patient data meta-analysis explained the associations between ACEs and substance misuse with adjustments for confounders such as sex and family structure. 1 in 2 participants reported child maltreatment ACEs and family level ACEs. Except for sexual abuse, males report more of every individual childhood adversity and are more likely to report misusing substances compared with females (87.3% vs. 12.7%). In adolescents, family level ACEs (adj OR 4.2, 95% CI 1.5–11.7) and collective level ACEs (adj OR 6.6, 95% CI 1.4–31.1) show associations with substance misuse whilst in young adults, child level ACEs such as maltreatment show similar strong associations (adj OR 2.0, 95% CI 1.1–3.5). ACEs such as abuse and domestic violence are strongly associated with substance misuse, most commonly tobacco, in adolescent and young adult males in India. The results suggest enhancing current ACE resilience programmes and ‘trauma-informed’ approaches to tackling longer-term impact of ACEs in India. Newton Bhabha Grant jointly funded by the Medical Research Council, UK (MR/N000390/1) and the Indian Council of Medical Research (ICMR/MRC-UK/3/M/2015-NCD-I). The online version contains supplementary material available at 10.1186/s12889-021-11892-5.
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影响因子：
50
作者：
Degli Esposti, Michelle;Humphreys, David K.;Bowes, Lucy
通讯作者：
Bowes, Lucy
影响因子：
--
作者：
Jayakrishnan, Radhakrishnan;Geetha, Seema;Sebastian, Paul
通讯作者：
Sebastian, Paul
影响因子：
4.4
作者：
Khubchandani, Jagdish;Sharma, Manoj;Tahiliani, Jay
通讯作者：
Tahiliani, Jay
影响因子：
2
作者：
Jackson D;Law M;Rücker G;Schwarzer G
通讯作者：
Schwarzer G
影响因子：
3.1
作者：
Jiloha, R. C.
通讯作者：
Jiloha, R. C.