Septo-hippocampal cholinergic system under the discrimination learning task in the rat: a microdialysis study with the dual-probe approach
Septo-hippocampal cholinergic system under the discrimination learning task in the rat: a microdialysis study with the dual-probe approach
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DOI：
10.1016/0006-8993(95)00290-7
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发表时间：
1995-06
期刊：
影响因子：
2.9
通讯作者：
Y. Yamamuro;K. Hori;J. Tanaka;H. Iwano;M. Nomura
中科院分区：
文献类型：
--
作者：
Y. Yamamuro;K. Hori;J. Tanaka;H. Iwano;M. Nomura
为探讨多巴胺能神经递质对辨别学习任务大鼠隔区-海马胆碱能系统的调节作用，采用双探针法体内微透析法。在操作型学习程序下，训练大鼠辨别灯亮和灯灭状态。在建立稳定的辨别行为后，将透析探针植入每只大鼠的海马区和外侧隔区。在学习开始后20分钟内，隔区多巴胺(DA)浓度迅速升高。然而，另一组大鼠接受了类似但非歧视任务的训练，结果没有出现这样的增长。在学习过程中，海马区的乙酰胆碱(ACh)浓度显著升高，并在学习结束后迅速恢复到基础值，但在非歧视组中表现出延迟和减弱的增加。这些结果表明，隔区的DA能输入可能参与了隔区-海马胆碱能系统的控制，这对辨别学习行为具有重要意义。
To investigate regulation of the septo-hippocampal cholinergic system by dopaminergic inputs to the septum in rats which performed a discrimination learning task, an in vivo microdialysis method with the dual-probe approach was used. Rats were trained to discriminate between lamp-on and -off states under an operant-type learning procedure. After stable discriminative behavior was established, dialysis probes were implanted into the hippocampus and the lateral septum area of each rat. The concentration of dopamine (DA) in the septum rapidly increased within 20 min after the beginning of a learning session. However, another group of rats trained on a similar but non-discriminative task showed no such increase. The concentration of acetylcholine (ACh) in the hippocampus was significantly enhanced during the learning session and rapidly returned to the basal value after the session, but showed a delayed and diminished increase in the non-discrimination group. These results suggest that DAergic inputs to the septum may be involved in control of the septo-hippocampal cholinergic system which is of importance for discrimination learning behavior.