Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases.
Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases.
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DOI：
10.1097/mco.0000000000000273
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发表时间：
2016-05
影响因子：
3.1
通讯作者：
Sacco A
中科院分区：
文献类型：
--
作者：
Sala D;Sacco A
本文综述了STAT3信号在骨骼肌再生和肌肉质量维持中的作用。STAT3信号在调节骨骼肌中多种细胞类型的功能中起着关键作用。这包括肌肉干细胞、肌纤维和巨噬细胞。它通过拮抗自我更新来调节肌肉干细胞功能。STAT3还在肌纤维中起作用以调节骨骼肌质量。这在STAT3活化促进蛋白质降解和肌肉萎缩的病理条件下是高度相关的。STAT3的短暂药理学抑制部分防止肌肉萎缩。然而，负责改善肌肉状况的机制目前还没有得到很好的理解。这是由于该系统的复杂性，因为STAT3在调节骨骼肌中几种细胞类型的功能方面具有关键作用。肌肉萎缩与几种人类疾病有关，如肌肉营养不良或癌症恶病质。然而，目前还没有有效的治疗方法，并且迫切需要确定新的潜在靶点以开发有效的治疗方法。
This review summarizes our current knowledge of the role of STAT3 signaling in skeletal muscle regeneration and the maintenance of muscle mass. STAT3 signaling plays a pivotal role in regulating the function of multiple cell types in skeletal muscle. This includes muscle stem cells, myofibers and macrophages. It regulates muscle stem cell function by antagonizing self-renewal. STAT3 also functions in myofibers to regulate skeletal muscle mass. This is highly relevant under pathological conditions where STAT3 activation promotes protein degradation and muscle atrophy. Transient pharmacological inhibition of STAT3 partially prevents muscle wasting. However, the mechanisms responsible for the improvement of muscle condition is not currently well understood. This is due to the complexity of the system, as STAT3 has a critical role in regulating the function of several cell types residing in skeletal muscle. Muscle wasting is associated with several human diseases such as muscle dystrophies or cancer cachexia. However, currently there are no effective treatments for this condition, and there is a critical need to identify new potential targets for the development of efficient therapeutic approaches.