ROLE OF CHOLANGIOLES IN RESTORATION OF THE LIVER OF THE MOUSE AFTER DIETARY INJURY
ROLE OF CHOLANGIOLES IN RESTORATION OF THE LIVER OF THE MOUSE AFTER DIETARY INJURY
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DOI：
10.1002/path.1700760213
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发表时间：
1958-01-01
期刊：
影响因子：
--
通讯作者：
LEDUC, EH
中科院分区：
文献类型：
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作者：
WILSON, JW;LEDUC, EH
给18至30日龄的小鼠喂食富含蛋氨酸的基础饮食与等量的膨润土混合。60至80天后，肝脏明显异常。实质细胞的体积大大增加，数量相应减少。这是由于分离的随机分布的实质细胞的死亡和去除;存活的实质细胞的大小增加，但不能分裂。在这些细胞之间有许多胆管，通过细胞的增厚和有丝分裂增殖而变得突出。如果有害的饮食被基础饮食所取代，肝脏的正常结构就会恢复。这种恢复包括原始的、扩大的实质细胞的持续死亡和消失，以及通过胆管细胞的转化产生新的、小的实质细胞。后者形成结节，显然代表Rappaport的功能单位。这些结节通过有丝分裂而扩大，新的实质细胞的大小增加，直到它们汇合并最终完全取代原始的实质。显然，在肝脏长期和严重损伤后，不可能通过预先存在的实质细胞分裂直接恢复，新的实质来自无关的胆管细胞。
Eighteen to 30-day-old mice were fed a methionine-rich basal diet mixed with an equal amount of bentonite. After 60 to 80 days the livers are strikingly abnormal. The parenchymal cells are enormously increased in size and correspondingly reduced in number. This results from death and removal of isolated, randomly distributed parenchymal cells; surviving parenchymal cells increase in size but are unable to divide. Between these cells are numerous cholangioles, which become prominent by thickening and mitotic proliferation of their cells. If the injurious diet is then replaced by a basal diet, the normal architectun of the liver is restored. This restoration involves continued death and disappearance of the original, enlarged parenchymal cells and production of new, small parenchymal cells by transformation of the cholangiole cells. The latter form nodules that apparently represent the functional units of Rappaport. These nodules enlarge by mitotic division and increase in size of the new parenchymal cells, until they become confluent and eventually replace the original parenchyma completely. Apparently after prolonged and severe injury to the liver which makes direct restoration by division of preexisting parenchymal cells impossible, the new parenchyma is derived from indifferent cholangiole cells.