Assessment of Cardiovascular Risk Factors and Their Interactions in the Risk of Coronary Heart Disease in Patients with Type 2 Diabetes with Different Weight Levels, 2013-2018.
Assessment of Cardiovascular Risk Factors and Their Interactions in the Risk of Coronary Heart Disease in Patients with Type 2 Diabetes with Different Weight Levels, 2013-2018.
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2013-2018年不同体重水平2型糖尿病患者心血管危险因素及其相互作用对冠心病风险的评估
DOI：
10.2147/dmso.s335017
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Wang C;Ye D;Xie Z;Huang X;Wang Z;Shangguan H;Zhu W;Wang S
除高血糖、高血脂外，肥胖、高血压是2型糖尿病患者发生冠心病的重要心血管危险因素。本研究旨在探讨这些危险因素之间的相互作用。收集了2013年至2018年T2 DM住院患者的数据。建立多因素Logistic回归模型。正常体重和血压的患者被招募作为对照。采用相对超额危险度（RERI）评价冠心病危险度的交互作用。在30，693例T2 DM患者中，7202例（23.5%）患有CHD。在低体重组中，高血压患者的冠心病患病率是非高血压患者的近4倍（42.7%比11.3%，P < 0.01）。单纯高血压对CHD的OR值从体重指数（BMI）30.0-34.9 kg/m2组的1.29（95%CI 1.06-1.56）增加到BMI ≤ 18.5 kg/m2组的1.35（95%CI 1.11-1.62）。在CHD风险中，高血压和BMI之间观察到叠加相互作用，特别是在低体重组中（RERI：2.2，95%CI 0.9-3.5）。BMI与CHD风险呈微笑曲线关系。低体重组的归因比例高于重度肥胖组，即0.52（95%CI 0.35-0.69）vs 0.18（95%CI-0.59 - 0.95）。对于合并糖尿病和高血压的患者，保持正常体重和避免低体重对于预防冠心病风险尤为重要。
In addition to hyperglycemia and hyperlipidemia, obesity and hypertension are important cardiovascular risk factors for coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM). This study aims to explore the interaction of these risk factors. Data of hospitalized patients with T2DM from 2013 to 2018 were collected. A multivariate logistic regression model was established. Patients with normal weight and blood pressure were recruited as controls. The interaction on the risk of CHD was evaluated by relative excess risk due to interaction (RERI). Among the 30,693 patients with T2DM, 7202 (23.5%) had CHD. In the low weight group, the prevalence of CHD in patients with hypertension was nearly four times higher than that in patients without hypertension (42.7% vs 11.3%, P < 0.01). The OR value of hypertension alone on CHD increased from 1.29 (95% CI 1.06–1.56) in the body mass index (BMI) 30.0–34.9 kg/m2 group to 1.35 (95% CI 1.11–1.62) in the BMI ≤ 18.5 kg/m2 group. Additive interaction was observed between hypertension and BMI in CHD risk, especially in the low weight group (RERI:2.2, 95% CI 0.9–3.5). BMI and CHD risk showed a smile curve relationship. The attributive proportion in the low weight group was higher than that in the severe obesity group, that is, 0.52 (95% CI 0.35–0.69) vs 0.18 (95% CI −0.59 to 0.95). Maintaining normal weight and avoiding low weight are particularly important for patients with co-occurring diabetes and hypertension to prevent the risk of CHD.
冠状动脉疾病候选心血管基因常见变异之间的基因-基因相互作用分析。
影响因子：
3.7
作者：
Musameh MD;Wang WY;Nelson CP;Lluís-Ganella C;Debiec R;Subirana I;Elosua R;Balmforth AJ;Ball SG;Hall AS;Kathiresan S;Thompson JR;Lucas G;Samani NJ;Tomaszewski M
通讯作者：
Tomaszewski M