Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X
Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X
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DOI：
10.1136/hrt.2009.192393
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发表时间：
2010-08-01
期刊：
影响因子：
5.7
通讯作者：
Chen, Jaw-Wen
中科院分区：
文献类型：
--
作者：
Huang, Shao-Sung;Huang, Po-Hsun;Chen, Jaw-Wen
研究背景心脏X综合征（CSX）患者的氧化应激和血管炎症增加。胆红素，曾经被认为是血红素降解的代谢终产物，已经成为动脉粥样硬化的潜在内源性抑制剂。本研究旨在评估血清胆红素在CSX患者疾病进展和临床结局中的预后作用。在冠状动脉造影前采集血液样本，检测血清胆红素水平。所有患者前瞻性随访5年的复合终点的总不良事件，包括死亡和非致命性心血管事件（非致命性心肌梗死，缺血性中风，再住院不稳定型心绞痛，冠状动脉血运重建）。结果有20例不良事件，包括5例死亡，5缺血性中风和10次再住院不稳定型心绞痛在随访期间。发生不良事件的患者基线血清胆红素水平较低（p
Background Increased oxidative stress and vascular inflammation have been demonstrated in patients with cardiac syndrome X (CSX). Bilirubin, once considered simply the metabolic end product of haem degradation, has emerged as a potential endogenous inhibitor of atherosclerosis. This study was conducted to evaluate the prognostic role of serum bilirubin in disease progression and clinical outcome in patients with CSX.Methods A total of 108 consecutive CSX patients were enrolled. Serum bilirubin levels were examined from blood samples collected before coronary angiography. All patients were prospectively followed up for 5 years for the composite end point of total adverse events including death and non-fatal cardiovascular events (non-fatal myocardial infarction, ischaemic stroke, rehospitalisation for unstable angina, and coronary revascularisation).Results There were 20 adverse events, including five deaths, five ischaemic strokes and 10 rehospitalisations for unstable angina during follow-up. Patients with adverse events had lower baseline serum bilirubin levels (p