Generalized F accelerated failure time model for mapping survival trait loci.
Generalized F accelerated failure time model for mapping survival trait loci.
复制标题
用于绘制生存性状基因座的广义 F 加速失效时间模型。
DOI：
10.1016/j.ygeno.2011.02.003
复制
发表时间：
2011
期刊：
影响因子：
4.4
通讯作者：
Yang,Runqing
中科院分区：
文献类型：
--
作者：
Zhou,Xiaojing;Yan,Li;Prows,DanielR;Yang,Runqing
加速失效时间（AFT）模型是生存分析中最常用的两种模型，它比考克斯比例风险模型（PHM）更容易拟合生存数据。在这项研究中，我们开发了一个通用的参数AFT模型用于识别生存性状基因座，其中灵活的广义F分布，包括许多常用的分布作为特殊情况，被指定为基线生存分布。给出了模型参数极大似然估计的EM算法。仿真结果验证了所提出的映射过程的灵活性和实用性。在分析F2交配群体小鼠高氧急性肺损伤（HALI）后的生存时间时，广义F分布在6个竞争生存分布中表现最好，并检测到4个控制HALI生存差异的QTL。
As the two most popular models in survival analysis, the accelerated failure time (AFT) model can more easily fit survival data than the Cox proportional hazards model (PHM). In this study, we develop a general parametric AFT model for identifying survival trait loci, in which the flexible generalizedFdistribution, including many commonly used distributions as special cases, is specified as the baseline survival distribution. EM algorithm for maximum likelihood estimation of model parameters is given. Simulations are conducted to validate the flexibility and the utility of the proposed mapping procedure. In analyzing survival time following hyperoxic acute lung injury (HALI) of mice in anF2mating population, the generalizedFdistribution performed best among the six competing survival distributions and detected four QTLs controlling differential HALI survival.