OCCURRENCE OF ALKANES IN BRAIN MYELIN - COMPARISON BETWEEN NORMAL AND QUAKING MOUSE
OCCURRENCE OF ALKANES IN BRAIN MYELIN - COMPARISON BETWEEN NORMAL AND QUAKING MOUSE
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DOI：
10.1111/j.1471-4159.1977.tb07781.x
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发表时间：
1977-01-01
影响因子：
4.7
通讯作者：
DARRIET, D
中科院分区：
文献类型：
--
作者：
BOURRE, JM;CASSAGNE, C;DARRIET, D
在小鼠脑中发现了烷烃，一种新的神经脂质，其水平在Quaking突变体中降低。这些碳氢化合物集中在髓磷脂中;在微粒体、线粒体和突触体中发现少量碳氢化合物。正常髓鞘的平均回收率为7.1 μ g/mg，震颤髓鞘的平均回收率为2.2 μ g/mg。这些烷烃的分布模式由GLC确定，并且在正常和震颤髓鞘中不同;碳氢化合物主要由具有偶数和奇数脂肪链的C21-C32的正烷烃组成。
Alkanes, a new class of neurolipid, were found in mouse brain, the level being reduced in the Quaking mutant. These hydrocarbons were concentrated in myelin; minor amounts being found in microsomes, mitochondria and synaptosomes. The average recovery is 7.1 .mu.g/mg in normal myelin, 2.2 in the Quaking myelin. The distribution pattern of these alkanes was determined by GLC and differed in normal and Quaking myelin; the hydrocarbons consist mainly of n-alkanes ranging from C21-C32 with even and odd aliphatic chains.