Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity
Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity
复制标题
DOI：
10.1016/j.virol.2013.01.018
复制
发表时间：
2013-04-25
期刊：
影响因子：
3.7
通讯作者：
Vasilakis, Nikos
中科院分区：
文献类型：
--
作者：
Durbin, Anna P.;Mayer, Sandra V.;Vasilakis, Nikos
森林登革热病毒（DENV）在进化和生态上都与人类登革热病毒不同，并维持在地方性传播周期中。来自西非和东南亚的森林人类感染证据表明，森林登革热病毒经常与人类接触。因此，这种进入人类传播周期的可能性可能会限制目前处于开发后期的疫苗根除这种周期的潜力。我们评估了在面对对当前人类毒株的自然免疫力和接种两种 DENV-4 候选疫苗的情况下森林化 DENV-4 出现的可能性。我们的数据表明，人类初级恢复期和疫苗接种者血清对森林和人类DENV-4毒株进行同型中和，但异型免疫有限。这些结果表明，森林菌株进入人类周期将受到自然感染或疫苗接种产生的病毒中和抗体介导的同型免疫的限制。 (C) 2013 Elsevier Inc. 保留所有权利。
Sylvatic dengue viruses (DENV) are both evolutionarily and ecologically distinct from human DENV and are maintained in an enzootic transmission cycle. Evidence of sylvatic human infections from West Africa and Southeast Asia suggests that sylvatic DENV come into regular contact with humans. Thus, this potential of emergence into the human transmission cycle could limit the potential for eradicating this cycle with vaccines currently in late stages of development. We assessed the likelihood of sylvatic DENV-4 emergence in the face of natural immunity to current human strains and vaccination with two DENV-4 vaccine candidates. Our data indicate homotypic neutralization of sylvatic and human DENV-4 strains by human primary convalescent and vaccinee sera but limited heterotypic immunity. These results suggest that emergence of sylvatic strains into the human cycle would be limited by homotypic immunity mediated by virus neutralizing antibodies produced by natural infection or vaccination. (C) 2013 Elsevier Inc. All rights reserved.