Metal-organic frameworks: mechanisms of antibacterial action and potential applications.
Metal-organic frameworks: mechanisms of antibacterial action and potential applications.
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DOI：
10.1016/j.drudis.2016.04.009
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发表时间：
2016-06
影响因子：
7.4
通讯作者：
Gabriela Wyszogrodzka;B. Marszalek;B. Gil;P. Dorożyński
中科院分区：
文献类型：
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作者：
Gabriela Wyszogrodzka;B. Marszalek;B. Gil;P. Dorożyński
金属-有机骨架具有显著的抗菌活性。mof可以用作抗菌剂或杀菌物质的载体。mof的抗菌作用与其他金属基纳米颗粒系统相似。mof的多孔结构提供了通往金属中心的开放通道。病原体对常规抗生素的耐药性日益增强，已成为一个公共卫生问题，需要寻求新的有效解决办法。金属-有机骨架（MOFs）是由有机结合配体连接的金属离子组成的多孔杂化材料。在mof中使用各种化学构建成分的可能性使形成具有所需性能的结构成为可能。它们可以作为金属离子的储存库，提供它们的逐渐释放，并产生持续的抗菌作用，类似于提出的金属/金属氧化物纳米颗粒（NPs），但不同于抗生素。这些特点使mof在制药和生物医学应用中有希望的候选者，正如本文讨论的例子所示。
HighlightsMetal-organic frameworks demonstrated significant antibacterial activity.MOFs may be used as antimicrobial agents or carriers of bactericidal substances.MOFs antibacterial action is similar to the other metal-based nanoparticulate systems.Porous structures of MOFs offer open access to the metal centers.The growing resistance of pathogens to conventional antibiotics has become a public health problem and raises the need to seek new effective solutions. Metal-organic frameworks (MOFs) are porous, hybrid materials comprising metal ions linked by organic binding ligands. The possibility of using a variety of chemical building components in MOFs enables the formation of structures with desired properties. They can act as a reservoir of metal ions, providing their gradual release and resulting in a sustained antibacterial action analogous to that proposed for metal/metal oxide nanoparticles (NPs) but different to that of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications, as illustrated by examples discussed in this review.