Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.
Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.
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红景天苷通过抑制铁凋亡减轻SAMP8小鼠肾纤维化
DOI：
10.3390/molecules27228039
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发表时间：
2022-11-19
期刊：
影响因子：
4.6
通讯作者：
Cheng, Weidong
中科院分区：
文献类型：
--
作者：
Yang, Sixia;Pei, Tingting;Wang, Linshuang;Zeng, Yi;Li, Wenxu;Yan, Shihua;Xiao, Wei;Cheng, Weidong
肾纤维化进展与衰老密切相关，最终导致肾功能障碍。红景天苷（SAL）被认为具有广泛的抗衰老作用。然而，SAL在衰老相关性肾纤维化中的作用和机制尚不清楚。本研究旨在评价SAL对SAMP 8小鼠的保护作用及其机制。SAMP 8小鼠给予SAL和铁抑素-1（Fer-I）12周。检测肾功能、肾组织纤维化程度及铁沉积。结果显示，SAL组大鼠升高的血尿素氮（BUN）和血肌酐（SCr）水平明显降低，血清白蛋白（ALB）水平升高，系膜增生明显减轻。SAL显著降低SAMP 8小鼠转化生长因子-β（TGF-β）和α-平滑肌肌动蛋白（α-sma）水平。SAL处理显著降低肾脏脂质过氧化反应，并调节铁转运相关蛋白和铁中毒相关蛋白。这些结果表明，SAL通过抑制SAMP 8小鼠的铁凋亡来延缓肾脏衰老并抑制衰老相关的肾小球纤维化。
Renal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) is considered to have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related renal fibrosis remain unclear. The study aimed to evaluate the protective effects and mechanisms of SAL in SAMP8 mice. SAMP8 mice were administered with SAL and Ferrostatin-1 (Fer-1) for 12 weeks. Renal function, renal fibrosis, and ferroptosis in renal tissue were detected. The results showed that elevated blood urea nitrogen (BUN) and serum creatinine (SCr) levels significantly decreased, serum albumin (ALB) levels increased, and mesangial hyperplasia significantly reduced in the SAL group. SAL significantly reduced transforming growth factor-β (TGF-β) and α-smooth muscle actin (α-sma) levels in SAMP8 mice. SAL treatment significantly decreased lipid peroxidation in the kidneys, and regulated iron transport-related proteins and ferroptosis-related proteins. These results suggested that SAL delays renal aging and inhibits aging-related glomerular fibrosis by inhibiting ferroptosis in SAMP8 mice.
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影响因子：
11.1
作者：
Sha R;Xu Y;Yuan C;Sheng X;Wu Z;Peng J;Wang Y;Lin Y;Zhou L;Xu S;Zhang J;Yin W;Lu J
通讯作者：
Lu J
影响因子：
3.9
作者：
Cao B;Zeng M;Si Y;Zhang B;Wang Y;Xu R;Huang Y;Feng W;Zheng X
通讯作者：
Zheng X
影响因子：
9
作者：
Kim S;Kang SW;Joo J;Han SH;Shin H;Nam BY;Park J;Yoo TH;Kim G;Lee P;Park JT
通讯作者：
Park JT
影响因子：
9.2
作者：
Huang Y;Wu B;Shen D;Chen J;Yu Z;Chen C
通讯作者：
Chen C
DOI：
10.1292/jvms.16-0204
发表时间：
2016-09-01
期刊：
The Journal of veterinary medical science
影响因子：
--
作者：
Taniguchi S;Hanafusa M;Tsubone H;Takimoto H;Yamanaka D;Kuwahara M;Ito K
通讯作者：
Ito K