Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
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DOI：
10.1038/nn872
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发表时间：
2002-07-01
影响因子：
25
通讯作者：
Markou, A
中科院分区：
文献类型：
--
作者：
Ahmed, SH;Kenny, PJ;Markou, A
向药物成瘾过渡的一个自相矛盾的方面是，药物使用者花费越来越多的时间和精力来获得药物快感，这种快感随着重复的经历而不断减少。根据享乐别稳态假说，对药物享乐效应的渴望和耐受性的增加是由于大脑奖赏功能调节（别稳态）的相同慢性改变造成的。在这里，我们表明，在大鼠中，反复退出长期可卡因自我管理产生持续减少大脑奖励功能，这是高度相关的可卡因摄入量的增加，并减少可卡因的快感的影响。
A paradoxical aspect of the transition to drug addiction is that drug users spend progressively more time and effort to obtain drug hedonic effects that continually decrease with repeated experience,. According to the hedonic allostasis hypothesis, increased craving for and tolerance to the hedonic effects of drugs result from the same chronic alteration in the regulation of brain reward function (allostasis). Here we show in rats that repeated withdrawals from prolonged cocaine self-administration produces a persistent decrease in brain reward function that is highly correlated with escalation of cocaine intake and that reduces the hedonic impact of cocaine.