Structure and Function of SLC4 Family [Formula: see text] Transporters.
Structure and Function of SLC4 Family [Formula: see text] Transporters.
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SLC4 家族 HCO3- 转运蛋白的结构和功能
DOI：
10.3389/fphys.2015.00355
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发表时间：
2015
影响因子：
4
通讯作者：
Chen LM
中科院分区：
文献类型：
--
作者：
Liu Y;Yang J;Chen LM
溶质载体SLC4家族由10个成员组成，其中9个为转运蛋白，包括3种不依赖钠离子的氯⁻/碳酸氢根交换体AE1、AE2和AE3，5种与钠离子偶联的转运蛋白NBCe1、NBCe2、NBCn1、NBCn2和NDCBE，以及其对钠离子依赖性仍存在争议的“AE4”。SLC4转运蛋白在pH调节和电解质跨上皮转运中发挥着关键作用，已证实具有广泛的生理相关性。这些转运蛋白功能异常与一系列人类疾病相关。在过去几十年里，人们付出了巨大努力来研究SLC4转运蛋白在质膜中的拓扑结构。基于提出的拓扑模型，突变和功能研究已确定了可能参与SLC4转运蛋白离子转运的重要结构元件。在本文中，我们综述了过去几十年在理解SLC4转运蛋白结构与功能方面所取得的进展。
The solute carrier SLC4 family consists of 10 members, nine of which are transporters, including three Na+-independent Cl−/ exchangers AE1, AE2, and AE3, five Na+-coupled transporters NBCe1, NBCe2, NBCn1, NBCn2, and NDCBE, as well as “AE4” whose Na+-dependence remains controversial. The SLC4 transporters play critical roles in pH regulation and transepithelial movement of electrolytes with a broad range of demonstrated physiological relevances. Dysfunctions of these transporters are associated with a series of human diseases. During the past decades, tremendous amount of effort has been undertaken to investigate the topological organization of the SLC4 transporters in the plasma membrane. Based upon the proposed topology models, mutational and functional studies have identified important structural elements likely involved in the ion translocation by the SLC4 transporters. In the present article, we review the advances during the past decades in understanding the structure and function of the SLC4 transporters.