Human herpesvirus 6 DNA in blood cells of human immunodeficiency virus-infected men: correlation of high levels with high CD4 cell counts.
Human herpesvirus 6 DNA in blood cells of human immunodeficiency virus-infected men: correlation of high levels with high CD4 cell counts.
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人类免疫缺陷病毒感染男性血细胞中的人类疱疹病毒 6 DNA：高水平与高 CD4 细胞计数的相关性。
DOI：
10.1093/infdis/169.6.1342
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Corey,L
中科院分区：
文献类型：
--
作者：
Fairfax,MR;Schacker,T;Cone,RW;Collier,AC;Corey,L
为探讨人类疱疹病毒6型(HHV-6)与人类免疫缺陷病毒1型(HIV-1)感染向艾滋病进展的关系，采用聚合酶链式反应定量分析了32例HIV-1阳性男性外周血单个核细胞(PBMC)和唾液中HHV-6基因组的等价物。与其他疱疹病毒不同，HHV-6在CD4细胞计数高而不是低的HIV感染男性中发现的频率更高，拷贝数也更多。在CD4细胞含量为400/ml的受试者中，100%的受试者PBMC中可检测到HHV-6基因组，而在受试者中，这一比例为57.9%(P<；0.05)。唾液中HHV-6抗体滴度、HHV-6DNA可扩增拷贝数与HIV疾病分期、CD4细胞数无明显相关性。
The relationship between human herpesvirus 6 (HHV-6) and the progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS was evaluated using the polymerase chain reaction to quantitate HHV-6 genome equivalents in peripheral blood mononuclear cells (PBMC) and saliva of 32 HIV-1-seropositive men. Unlike other herpesviruses, HHV-6 was found with higher frequency and in higher copy numbers in HIV-infected men with high rather than low CD4 cell counts. Among subjects with >400 CD4 cells/mL, 100% had detectable HHV-6 genomes in PBMC compared with 57.9% of subjects with <400 CD4 cells/mL (P< .05). There was no significant correlation between HHV-6 antibody titer or number of amplifiable copies of HHV-6 DNA in saliva and stage of HIV disease or CD4 cell number.