Gait phenotype from mild cognitive impairment to moderate dementia: results from the GOOD initiative.
Gait phenotype from mild cognitive impairment to moderate dementia: results from the GOOD initiative.
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DOI：
10.1111/ene.12882
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发表时间：
2016-03
影响因子：
5.1
通讯作者：
Beauchet O
中科院分区：
文献类型：
--
作者：
Allali G;Annweiler C;Blumen HM;Callisaya ML;De Cock AM;Kressig RW;Srikanth V;Steinmetz JP;Verghese J;Beauchet O
步态异常的差异，从最早期到后期的痴呆症和不同亚型的痴呆症还没有得到充分的研究。本研究旨在比较认知健康个体、遗忘型（aMCI）和非遗忘型（naMCI）MCI患者以及轻度和中度阿尔茨海默病（AD）和非阿尔茨海默病（non-AD）患者的时空步态参数。基于横断面设计，从参与“步态、认知和衰退”倡议的七个国家的队列中招募了1719名参与者（77.4±7.3岁，53.9%女性）。在所有站点使用GAITRite系统在正常步速行走期间测量时空步态参数的平均值和变异系数。时空步态参数的性能下降平行的认知能力下降的阶段，从MCI状态到中度痴呆。与aMCI患者相比，naMCI患者的步态参数受到更多干扰，MCI亚组的表现优于痴呆患者。非AD痴呆患者的步态表现比AD痴呆患者差。这种退化的步态参数是相似的平均值和时空步态参数的变异系数在认知能力下降的最早阶段，但不同的最先进的阶段，特别是在非AD亚型。时空步态参数在痴呆的晚期更受干扰，在非AD痴呆比AD更受影响。这些研究结果表明，定量步态参数可以作为一个替代指标，以提高痴呆的诊断。
The differences in gait abnormalities from the earliest to the latter stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatio-temporal gait parameters in cognitively healthy individuals, patients with amnestic (aMCI) and non-amnestic (naMCI) MCI, and patients with mild and moderate stages of Alzheimer’s disease (AD) and non-Alzheimer’s disease (non-AD). Based on a cross-sectional design, 1719 participants (77.4±7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the “Gait, cOgnitiOn & Decline” initiative. Mean values and coefficients of variation of spatio-temporal gait parameters were measured during normal pace walking with the GAITRite system at all sites. Performance of spatio-temporal gait parameters declined in parallel to the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with naMCI were more disturbed compared to patients with aMCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of the gait parameters was similar between mean values and coefficients of variation of spatio-temporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes. Spatio-temporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.