Plasmodium falciparum genotypes, low complexity of infection, and resistance to subsequent malaria in participants in the Asembo Bay cohort project
Plasmodium falciparum genotypes, low complexity of infection, and resistance to subsequent malaria in participants in the Asembo Bay cohort project
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DOI：
10.1128/iai.69.12.7783-7792.2001
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发表时间：
2001-12-01
影响因子：
3.1
通讯作者：
Lal, AA
中科院分区：
文献类型：
--
作者：
Branch, OH;Takala, S;Lal, AA
为了评估疟疾感染的宿主内多样性与宿主对随后感染的易感性之间的关系，我们对60名儿童从出生到3岁的连续感染进行了基因分型。MSP-1 Block 2基因型用于估计感染复杂性（COI）。K1和Mad 20等位基因检出数与疟疾传播史、年龄呈正相关（P < 0.003）。控制先前的寄生虫血症、传播、药物治疗、寄生虫密度、镰状细胞和年龄，COIKM与对> 500/穆尔的寄生虫血症的抗性呈负相关（P < 0.0001）。携带RO-基因型的寄生虫感染者比不携带RO-基因型的寄生虫感染者耐药率高（P < 0.0000）。COIKM低感染者的耐药无基因型特异性。我们讨论了基因型超越免疫保守抗原决定簇的影响。我们还提出了一个多样性驱动的免疫调节假说，可以解释在生命的最初几年自然免疫的延迟发展，并建议减少COIKM的干预措施可以促进保护性免疫的发展。
To assess the relationship between the within-host diversity of malaria infections and the susceptibility of the host to subsequent infection, we genotyped 60 children's successive infections from birth through 3 years of life. MSP-1 Block2 genotypes were used to estimate the complexity of infection (COI). Malaria transmission and age were positively associated with the number of K1 and Mad20 alleles detected (COIKM) (P < 0.003). Controlling for previous parasitemia, transmission, drug treatment, parasite density, sickle cell, and age, COIKM was negatively correlated with resistance to parasitemia of > 500/mul (P < 0.0001). Parasitemias with the RO-genotype were more resistant than those without this genotype (P < 0.0000). The resistance in low COIKM infections was not genotype specific. We discuss the impact of genotype-transcending immunity to conserved antigenic determinants. We also propose a diversity-driven immunomodulation hypothesis that may explain the delayed development of natural immunity in the first few years of life and suggest that interventions that decrease the COIKM could facilitate the development of protective immunity.