The repairability of oxidative free radical mediated damage to DNA: a review.

The repairability of oxidative free radical mediated damage to DNA: a review.
复制标题

氧化自由基介导的 DNA 损伤的可修复性:综述。

DOI:
--
复制
发表时间:
1988
影响因子:
2.6
通讯作者:
Jean Cadet
Jean Cadet
中科院分区:
医学3区
文献类型:
--
作者:
G. Teebor;R. Boorstein;Jean Cadet

文献摘要

参考文献

被引文献

相似文献

许多DNA修复酶活性存在于原核生物和真核生物中。其中包括DNA外核酸酶和内切酶以及DNA糖基化酶,它们去除DNA分子的氧化损伤部分,从而启动切除修复。这些酶的存在可以作为细胞DNA持续受到内源性氧化应激的证据。许多由电离和紫外线辐射引入的损伤与由活化的白细胞产生的活性氧引入DNA的损伤相同,并且是修复酶的底物。描述了病变的化学性质、生物效应和可修复性机制。
Many DNA repair enzyme activities are present in both prokaryotic and eukaryotic organisms. Among these are DNA exo- and endonucleases and DNA glycosylases which remove oxidatively damaged portions of the DNA molecule, thereby initiating excision-repair. The existence of these enzymes may be taken as evidence that cellular DNA is continuously subject to endogenous oxidative stress. Many of the lesions introduced by ionizing and ultraviolet radiation are identical to those introduced into DNA by reactive oxygen species generated by activated white cells, and are substrates for the repair enzymes. The chemical nature of the lesions, their biologic effects, and the mechanism of their repairability are described.
3-氨基苯甲酰胺对 DNA 中含有 5-羟甲基尿嘧啶的中国仓鼠细胞的毒性。
DOI: --
发表时间: 1987
期刊: Cancer research
影响因子: 11.2
作者:
Boorstein,RJ;Levy,DD;Teebor,GW
通讯作者: Teebor,GW
DOI: 10.1093/nar/14.2.737
发表时间: 1986-01-24
影响因子: 14.9
作者:
CLARK, JM;BEARDSLEY, GP
通讯作者: BEARDSLEY, GP
5-羟甲基-2-脱氧尿苷(电离辐射产物)的遗传效应。
DOI: 10.1016/0027-5107(87)90267-3
发表时间: 1987
期刊: Mutation research
影响因子: --
作者:
Shirnamé-Moré,L;Rossman,TG;Troll,W;Teebor,GW;Frenkel,K
通讯作者: Frenkel,K
DOI: 10.2307/3576847
发表时间: 1986-07
期刊: Radiation research
影响因子: 3.4
作者:
S. Chiu;L. Friedman;N. M. Sokany;L. Xue;N. Oleinick
通讯作者: S. Chiu;L. Friedman;N. M. Sokany;L. Xue;N. Oleinick
γ-辐射 DNA 中顺式胸苷乙二醇非对映异构体的定量测量。
DOI: 10.3109/10715768709065296
发表时间: 1987
期刊: Free radical research communications
影响因子: --
作者:
Teebor,G;Cummings,A;Frenkel,K;Shaw,A;Voituriez,L;Cadet,J
通讯作者: Cadet,J