Cortical and collicular inputs to cells in the rat paralaminar thalamic nuclei adjacent to the medial geniculate body.
Cortical and collicular inputs to cells in the rat paralaminar thalamic nuclei adjacent to the medial geniculate body.
复制标题
皮质和丘脑输入到与内侧膝状体相邻的大鼠旁层丘脑核中的细胞。
DOI：
10.1152/jn.00235.2007
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发表时间：
2007
影响因子：
2.5
通讯作者：
Kowalkowski,Anna
中科院分区：
文献类型：
--
作者：
Smith,PhilipH;Bartlett,EdwardL;Kowalkowski,Anna
包括内侧膝状体核内侧部在内的丘脑腹外侧核团在内侧和腹侧包围着听丘脑。这个多模式区域接收来自听觉、视觉和躯体感觉结构的会聚输入，并将发散输出发送到皮层第一层、杏仁核、基底神经节和其他地方。研究表明，该区域参与调节皮质40 Hz振荡、皮质信息绑定和条件性恐惧反应。我们最近发现，丘脑神经元的基本解剖和内在生理学不同于感觉丘脑其他部位的神经元。在这里，我们评估了从下丘、上级丘和皮层到小脑板细胞的突触输入。结合生理和解剖学证据表明，丘脑细胞接受来自丘和兴奋性皮层输入的兴奋性和抑制性输入。来自所有三个来源的兴奋性输入通常产生由AMPA和NMDA组分组成的小的总和EPSP，并且主要终止于较小的树突，偶尔终止于树突棘。皮层输入表现出强的成对脉冲易化（PPF），而两个丘输入表现出弱的PPF或成对脉冲抑制（PPD）。当细胞超极化时，没有低阈值钙电导的细胞的EPSP不会引起爆发反应。较长的潜伏期EPSPs被认为是和我们的证据表明，这些产生的轴突侧支输入的其他突触激活的神经元细胞。抑制性丘输入是GABA能的，激活GABA A受体，并终止于树突。它们的激活能显著改变EPSP发放的峰电位数目和发放时间。
The paralaminar nuclei, including the medial division of the medial geniculate nucleus, surround the auditory thalamus medially and ventrally. This multimodal area receives convergent inputs from auditory, visual, and somatosensory structures and sends divergent outputs to cortical layer 1, amygdala, basal ganglia, and elsewhere. Studies implicate this region in the modulation of cortical 40-Hz oscillations, cortical information binding, and the conditioned fear response. We recently showed that the basic anatomy and intrinsic physiology of paralaminar cells are unlike that of neurons elsewhere in sensory thalamus. Here we evaluate the synaptic inputs to paralaminar cells from the inferior and superior colliculi and the cortex. Combined physiological and anatomical evidence indicates that paralaminar cells receive both excitatory and inhibitory inputs from both colliculi and excitatory cortical inputs. Excitatory inputs from all three sources typically generate small summating EPSPs composed of AMPA and NMDA components and terminate primarily on smaller dendrites and occasionally on dendritic spines. The cortical input shows strong paired-pulse facilitation (PPF), whereas both collicular inputs show weak PPF or paired-pulse depression (PPD). EPSPs of cells with no low-threshold calcium conductance do not evoke a burst response when the cell is hyperpolarized. Longer-latency EPSPs were seen and our evidence indicates that these arise from axon collateral inputs of other synaptically activated paralaminar cells. The inhibitory collicular inputs are GABAergic, activate GABAAreceptors, and terminate on dendrites. Their activation can greatly alter EPSP-generated spike number and timing.