Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice
Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice
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DOI：
10.1016/j.jep.2006.03.003
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发表时间：
2006-09-19
影响因子：
5.4
通讯作者：
Chojnacka-Wojcik, E.
中科院分区：
文献类型：
--
作者：
Wesolowska, A.;Nikiforuk, A.;Chojnacka-Wojcik, E.
对野生菜和菊苣中特有的苦味倍半萜内酯类化合物乳糖苷(1)及其衍生物乳果苦苷(2)和11β，13-二氢乳糖苷(3)进行了小鼠的镇痛和镇静作用研究。在热板实验中，15 mg/kg和30 mg/kg剂量的化合物表现出与标准药物布洛芬30 mg/kg相似的镇痛作用。在甩尾实验中，化合物30 mg/kg的镇痛活性与60 mg/kg布洛芬相当。乳果苦苷似乎是三种被测试化合物中最有效的止痛剂。在自发活动试验中，乳糖苷和乳糖苷也表现出镇静作用，而11β，13-二氢乳糖素则不然。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Lactucin (1) and its derivatives lactucopicrin (2) and 11 beta,13-dihydrolactucin (3), which are characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were evaluated for analgesic and sedative properties in mice. The compounds showed analgesic effects at doses of 15 and 30 mg/kg in the hot plate test similar to that of ibuprofen, used as a standard drug, at a dose of 30 mg/kg. The analgesic activities of the compounds at a dose of 30 mg/kg in the tail-flick test were comparable to that of ibuprofen given at a dose of 60 mg/kg. Lactucopicrin appeared to be the most potent analgetic of the three tested compounds. Lactucin and lactucopicrin, but not 11 beta, 13-dihydrolactucin, also showed sedative properties in the spontaneous locomotor activity test. (c) 2006 Elsevier Ireland Ltd. All rights reserved.