Recent studies on terpenoids in Aspergillus fungi: Chemical diversity, biosynthesis, and bioactivity
Recent studies on terpenoids in Aspergillus fungi: Chemical diversity, biosynthesis, and bioactivity
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DOI：
10.1016/j.phytochem.2021.113011
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发表时间：
2021-11-11
期刊：
影响因子：
3.8
通讯作者：
Ma, Xiao-Chi
中科院分区：
文献类型：
--
作者：
Zhao, Wen-Yu;Yi, Jing;Ma, Xiao-Chi
真菌代谢产物是除植物外天然小分子药物的主要来源，而真菌来源的萜类化合物已被证实在许多疾病中具有巨大的潜力。曲霉属真菌广泛分布于地球的各个角落，其萜类代谢产物在化学性质和生物活性方面表现出多样性。本文对近十年来曲霉属植物中萜类化合物的化学、生物合成和生物学研究进行了综述，包括单萜、倍半萜、二萜、六萜、三萜和部分萜。介绍了288种萜类化合物的结构特征、生物合成及药理活性。
Metabolites from fungi are a major source of natural small molecule drugs in addition to plants, while fungal derived terpenoids have been confirmed to have great potentials in many diseases. Aspergillus fungi are distributed in every corner of the earth, and their terpenoid metabolites exhibit promising diversity in term of both their chemistry and bioactivity. This review attempted to provide timely and comprehensive coverage of chemical, biosynthesis, and biological studies on terpenoids discovered from the genus Aspergillus, including mono-, sesqui-, di-, sester-, tri-, and meroterpenoids, in the last decade. The structural characteristics, biosynthesis, and pharmacological activities of 288 terpenoids were introduced.