Cooperation between independent hippocampal synapses is controlled by glutamate uptake
Cooperation between independent hippocampal synapses is controlled by glutamate uptake
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DOI：
10.1038/nn825
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发表时间：
2002-04-01
影响因子：
25
通讯作者：
Scanziani, M
中科院分区：
文献类型：
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作者：
Arnth-Jensen, N;Jabaudon, D;Scanziani, M
释放的神经递质的局部作用是突触独立性的基础。在突触密集分布的海马神经纤维层，推测通过释放谷氨酸，从突触间隙扩散出去，也可能激活邻近突触的突触后受体。在此，我们发现，海马CA1区锥体细胞上相邻的兴奋性突触可以通过释放的谷氨酸汇聚来协同激活突触后受体，并且这种协同作用是由谷氨酸摄取控制的。此外，谷氨酸转运体控制来自同一轴突的递质瞬变之间的时间相互作用。因此，兴奋性突触之间的协同作用在空间和时间上都受到谷氨酸摄取的调节。
Localized action of released neurotransmitters is the basis for synaptic independence. In the hippocampal neuropil, where synapses are densely packed, it has been postulated that released glutamate, by diffusing out of the synaptic cleft, may also activate postsynaptic receptors at neighboring synapses. Here we show that neighboring excitatory synapses on hippocampal CA1 pyramidal cells can cooperate in the activation of postsynaptic receptors through the confluence of released glutamate, and that this cooperation is controlled by glutamate uptake. Furthermore, glutamate transporters control temporal interactions between transmitter transients originating from the same axon. Thus, cooperative interactions between excitatory synapses are modulated in space and time by glutamate uptake.