Sperm cystic fibrosis transmembrane conductance regulator expression level is relevant to fecundity of healthy couples.
Sperm cystic fibrosis transmembrane conductance regulator expression level is relevant to fecundity of healthy couples.
复制标题
精子囊性纤维化跨膜电导调节因子的表达水平与健康夫妇的生育力相关。
作者：
Sun P-B;Xu H-M;Li K;Li H-C;Chen A-J;Chen M-J;Dai H-T;Ni Y
囊性纤维化跨膜传导调节因子（CFTR）与精子质量、精子获能和男性生育力有关。然而，CFTR是否可以作为健康夫妇生育力预测的潜在参数仍然是未知的。在这项研究中，135对健康夫妇根据他们的生育能力分组。结果表明，未与配偶受孕的健康男性精子CFTR表达水平（49例，38.68 ± 2.71%）显著低于有生育能力的男性（86例，46.35 ± 2.32%）。精子CFTR表达水平与生育力通过Logistic回归模型准确对应。受试者工作特征（ROC）曲线分析显示，精子CFTR表达水平预测生育力的截断值为43.75%。此外，CFTR > 43.75%组和CFTR ≤ 43.75%组在随访期间的累积妊娠率（CPR）分别为80.6%和49.3%。CFTR ≤ 43.75%组的平均妊娠时间（TTP）（26.79 ± 2.35）显著长于CFTR > 43.75%组（16.46 ± 2.42）。因此，精子CFTR表达水平与健康夫妇的生育力相关，具有潜在的预测生育力的能力。
Cystic fibrosis transmembrane conductance regulator (CFTR) is relevant to sperm quality, sperm capacitation and male fertility. However, it is still unknown whether CFTR can be a potential parameter for fecundity prediction in healthy couples. In this study, 135 healthy couples were divided into groups according to their fertility. We demonstrated that the sperm CFTR expression level of healthy males who never impregnated their partners (49 cases, 38.68 ± 2.71%) was significantly lower than that of fertile men (86 cases, 46.35 ± 2.32%). Sperm CFTR expression level accurately corresponded with fertility through the logistic regression model. Receiver operating characteristic (ROC) curve analysis showed that the cut‐off value of sperm CFTR expression level for fecundity prediction was 43.75%. Furthermore, cumulative pregnancy rates (CPRs) of CFTR > 43.75% group and CFTR ≤ 43.75% group during the follow‐up periods were 80.6% and 49.3% respectively. Meanwhile, the mean time to pregnancy (TTP) of CFTR ≤ 43.75% group (26.79 ± 2.35) was significantly longer than that of CFTR > 43.75% group (16.46 ± 2.42). Therefore, sperm CFTR expression level is relevant to fecundity of healthy couples and shows potential predictive capacity of fecundity.