Copper/DIPEA-Catalyzed, Aldehyde-Induced Tandem Decarboxylation-Coupling of Natural α-Amino Acids and Phosphites or Secondary Phosphine Oxides
Copper/DIPEA-Catalyzed, Aldehyde-Induced Tandem Decarboxylation-Coupling of Natural α-Amino Acids and Phosphites or Secondary Phosphine Oxides
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DOI：
10.1021/jo200981h
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发表时间：
2011-08-05
影响因子：
3.6
通讯作者：
Wang, Rui
中科院分区：
文献类型：
--
作者：
Yang, Dongxu;Zhao, Depeng;Wang, Rui
开发了铜/DIPEA 催化、醛诱导的天然α-氨基酸和亚磷酸酯或仲氧化膦的分子间脱羧偶联反应。在此过程中，获得了一系列潜在有用的有机合成配体和生物学上重要的非天然氨基酸衍生物（叔氨基磷化合物）。
A copper/DIPEA-catalyzed, aldehyde-induced intermolecular decarboxylative coupling reaction of natural a-amino acids and phosphites or secondary phosphine oxides was developed. In this process, a series of potentially useful ligands for organic synthesis and biologically important unnatural amino acid derivatives (tertiary amino phosphorus compounds) were obtained.