Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis
Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis
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DOI：
10.1093/ndt/gfh654
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发表时间：
2005-03-01
影响因子：
6.1
通讯作者：
Novak, M
中科院分区：
文献类型：
--
作者：
Mucsi, F;Molnar, MZ;Novak, M
背景在一项横断面研究中，我们分析了不宁腿综合征（RLS）、失眠和特定失眠症状与维持性透析患者健康相关生活质量（QoL）之间的复杂关系。数据来自333例长期维持透析患者。为了评估RLS的患病率，我们使用了RLS问卷（RLSQ）。采用雅典失眠量表（AIS）评估失眠，采用肾脏疾病生活质量量表（QQI）评估生活质量。RLS的患病率为14%。与无RLS的患者相比，有RLS的患者的共病情况显著更多（中位数：3比2; P < 0.05）。RLS患者发生严重失眠的可能性是无RLS患者的两倍（35%比16%; P < 0.05）。此外，RLS与总体睡眠质量受损（AIS评分中位数：8比4; P < 0.01）和较差的QoL相关。在对临床和社会人口统计学协变量进行统计学调整后，RLS是几个QoL领域的显著和独立预测因子。重要的是，即使在调整睡眠质量后，这种关联仍然显着。RLS与维持性透析患者的睡眠不良、失眠几率增加和生活质量受损相关。根据目前的研究结果，我们认为，睡眠相关和睡眠无关的因素可能赋予RLS对生活质量的影响。
Background. In a cross-sectional study, we analysed the complex relationship between restless legs syndrome (RLS), insomnia and specific insomnia symptoms and health-related quality of life (QoL) in patients on maintenance dialysis.Methods. Data were obtained from 333 patients on chronic maintenance dialysis. To assess the prevalence of RLS, we used the RLS Questionnaire (RLSQ). The Athens Insomnia Scale (AIS) was used to assess insomnia and QoL was measured with the Kidney Disease Quality-of-Life Questionnaire.Results. The prevalence of RLS was 14%. The number of comorbid conditions was significantly higher in patients with vs without RLS (median: three vs two; P < 0.05). RLS patients were twice as likely to have significant insomnia as patients without RLS (35% vs 16%; P < 0.05). Furthermore, RLS was associated with impaired overall sleep quality (median AIS score: 8 vs 4; P < 0.01) and poorer QoL. RLS was a significant and independent predictor of several of the QoL domains after statistical adjustment for clinical and socio-demographic covariables. Importantly, this association remained significant even after adjusting for sleep quality.Conclusions. RLS is associated with poor sleep, increased odds for insomnia and impaired QoL in patients on maintenance dialysis. Based on the present results, we suggest that both sleep-related and sleep-independent factors may confer the effect of RLS on QoL.