A self-assembled fluorescent organic nanoprobe and its application for sulfite detection in food samples and living systems
A self-assembled fluorescent organic nanoprobe and its application for sulfite detection in food samples and living systems
复制标题
自组装荧光有机纳米探针及其在食品样品和生命系统中亚硫酸盐检测中的应用
DOI：
10.1039/c7ob00580f
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发表时间：
2017-05-28
影响因子：
3.2
通讯作者：
Zeng, Wenbin
中科院分区：
文献类型：
--
作者：
Gao, Tang;Cao, Xiaozheng;Zeng, Wenbin
二氧化硫（SO2）是一种广泛分布的空气污染物，人类很容易通过吸入SO2而接触亚硫酸盐，从而诱发呼吸道反应和疾病。因此，开发一种快速、灵敏、选择性检测亚硫酸盐的方法具有重要意义。在此，我们设计并合成了一种具有聚集诱导发射增强（AIEE）功能的新型四苯基咪唑化合物TIBM。 TIBM 可以自组装成组织良好的纳米颗粒，据报道是一种具有高选择性和灵敏度的出色的亚硫酸盐检测探针。该纳米探针在亚硫酸盐的检测中表现非常好，具有超快的检测时间（15 s）和超低的检测限（7.4 nM），优于大多数已报道的探针。此外，纳米探针已成功用于检测食品样品中的亚硫酸盐，并且具有良好的准确性。此外，我们还开发了用于肉眼即时检测亚硫酸盐的纸质设备。此外，由于其高水溶性、细胞膜渗透性和良好的生物相容性，纳米探针被进一步应用于检测生命系统中的亚硫酸盐。这项研究可能为设计其他用于各种分析物的基于 AIE 的荧光纳米传感器提供一些有用的见解。
Sulfur dioxide (SO2) is a widely distributed air pollutant, and humans can easily be exposed to sulfite by inhaling SO2, thus inducing respiratory responses and diseases. Hence, to develop a rapid, sensitive and selective method for detection of sulfites is of great importance. Herein, we designed and synthesized a novel tetraphenyl imidazole compound TIBM with aggregation-induced emission enhancement (AIEE). TIBM can self-assemble into well-organized nanoparticles and is reported as an excellent probe for detection of sulfite with high selectivity and sensitivity. The nanoprobe performed very well for the detection of sulfite with an ultrafast detection time (15 s) and an ultralow detection limit (7.4 nM), which is superior to most of the reported probes. Moreover, the nanoprobe was successfully used to detect sulfite in food samples with a favorable accuracy. In addition, we developed paper-based devices for point-of-care detection of sulfite with naked eyes. Furthermore, due to its high water solubility, cell membrane permeability and good biocompatibility, the nanoproboe was further applied to detect sulfite in living systems. This study may offer some helpful insights for designing other AIE-based fluorescent nanosensors for various analytes.