Growth, developmental stability and immune response in juvenile Japanese quails (Coturnix coturnix japonica)
Growth, developmental stability and immune response in juvenile Japanese quails (Coturnix coturnix japonica)
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DOI：
10.1098/rspb.1999.0840
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发表时间：
1999-09-07
影响因子：
4.7
通讯作者：
Ricklefs, RE
中科院分区：
文献类型：
--
作者：
Fair, JM;Hansen, ES;Ricklefs, RE
压力是限制生长或导致生物体潜在不利变化的环境因素。发育中的生物体暴露于环境压力可能会产生几种生理后果，包括免疫能力下降。然而，建立针对外来抗原的免疫应答本身可能构成开发生物体的成本。这种成本对成年人的功能和健康有潜在的长期影响。本研究探讨了日本鹌鹑小鸡的生长和发育稳定性的挑战，由三个非致病性抗原：绵羊红细胞，评估T细胞依赖的免疫反应，支原体滑膜和纽卡斯尔病病毒，评估T细胞非依赖性的反应。与对照鸟相比，抗原攻击的鸟的体重和翅长的增加显著减少。波动不对称性（FA）在初级羽毛的质量增加，从最里面的（1）到最外面的（10）的位置上的翅膀。此外，M.滑膜炎和绵羊红细胞与FA增加相关。通过对植物血凝素的反应来测量细胞介导的反应在hi中被显著抑制。滑液挑战鸟类。除单核细胞外，白色血细胞计数在所有三种抗原处理后均升高。总血浆蛋白和红细胞压积在治疗之间也存在差异，但与抗原攻毒无明显关系。免疫反应显然对发育中的小鸡施加了压力。需要进行更多的研究，以确定发育应激的长期后果，并评估影响雏鸡免疫反应强度的选择性力量。
Stresses are environmental factors which restrict growth or cause a potentially adverse change in an organism. The exposure of developing organisms to environmental stresses may have several physiological consequences including a decrease in immunocompetence. However, mounting an immune response against a foreign antigen may in itself constitute a cost for developing organisms. This cost has potentially long-term consequences for adult function and fitness. This study examines the growth and developmental stability of Japanese quail chicks challenged by three non-pathogenic antigens: sheep red blood cells, which assess T-cell-dependent immune responses, and Mycoplasma synoviae and Newcastle disease virus, which assess T-cell-independent responses. Increases in both body mass and wing length were significantly reduced in antigen-challenged birds compared to control birds. Fluctuating asymmetry (FA) in the masses of primary feathers increased from the innermost (1) to the outermost (10) position on the wing. In addition, antigen challenge by M. synoviae and sheep red blood cells was associated with an increase in FA. The cell-mediated response measured by reaction to phytohaemagglutinin was significantly depressed in hi. synoviae-challenged birds. White blood cell counts, except for monocytes, were elevated in response to all three antigen treatments. Total plasma protein and haematocrit also differed between treatments but exhibited no clear relationship to antigen challenge. Immune responses clearly impose a stress on developing chicks. Additional research will be required to determine the long-term consequences of developmental stress and assess the selective forces that influence the strength of the immune responses of chicks.