Role of the prevalent Anopheles species in the transmission of Plasmodium falciparum and P-vivax in Assam state, north-eastern India
Role of the prevalent Anopheles species in the transmission of Plasmodium falciparum and P-vivax in Assam state, north-eastern India
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DOI：
10.1179/000349804225021361
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发表时间：
2004-09-01
影响因子：
--
通讯作者：
Mahanta, J
中科院分区：
文献类型：
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作者：
Prakash, A;Bhattacharyya, DR;Mahanta, J
在印度东北部，微小按蚊（Anopheles minimus）、小按蚊（An. dirus和安.河栖疟原虫被认为是引起人类疟疾的三种主要寄生虫媒介。然而，在该地区存在的其他按蚊物种的传播中的作用并不十分清楚。为了研究更常见的按蚊的媒介作用，在ELISA中测试了属于16个种的4126只雌性按蚊的头部和胸部（使用设置在阿萨姆邦Jorhat区的山麓村庄的人类住宅中的微型光陷阱收集），用于恶性疟原虫的环子孢子蛋白（CSP）或间日疟原虫的VK-210和VK-247多态性。发现代表10种不同按蚊的65个头胸匀浆池具有反应性，总体最低感染率（MPI）为1.58%，95%置信区间（CI）为1.21%-2.0%。在CSP反应性蚊子库中，31%仅对恶性疟原虫呈阳性，45%仅对间日疟原虫VK 247呈阳性，6%仅对间日疟原虫VK 210呈阳性，18%对恶性疟原虫和间日疟原虫VK 247均呈阳性。结果表明，不仅已证明的矢量，An。小肌(MPI=0.71%），但也有几种按蚊以前被认为是不重要的疟疾流行病学，特别是一个。乌头属（MPI = 3.95%）、乌头属（An. annularis（MPI = 5.8%）、An.赫坎氏组（MPI = 0.48%）、安氏按蚊（An. kochi（MPI = 1.28%）、An. philippinensis-nivipes复合体（MPI = 0.94%）;迷走神经（MPI = 3.87%），是重要的媒介在阿萨姆山麓。
In north-eastern India, Anopheles minimus, An. dirus and An. fluviatilis are considered the three major vectors of the parasites causing human malaria. The role in transmission of the other Anopheles species present in this region is not, however, very clear. To examine the vectorial role of the more common anopheline mosquitoes, the heads and thoraces of 4126 female Anopheles belonging to 16 species (collected using miniature light traps set in human dwellings in a foothill village in the Jorhat district of Assam state) were tested, in ELISA, for the circumsporozoite proteins (CSP) of Plasmodium falciparum or the VK-210 and VK-247 polymorphs of P. vivax. Sixty-five pools of head-thorax homogenates, representing 10 different species of Anopheles, were found reactive, giving an overall minimum prevalence of infection (MPI) of 1.58%, with a 95% confidence interval (CI) of 1.21%-2.0%. Among the CSP-reactive pools of mosquitoes, 31% were positive only for P. falciparum, 45% only for P. vivax VK 247, 6% only for P. vivax VK 210, and 18% for both P. falciparum and P. vivax VK 247. The results indicate that not only the proven vector, An. minimus s.I. (MPI=0.71%), but also several species of Anopheles previously considered unimportant in the epidemiology of malaria, especially An. aconitus (MPI = 3.95%), An. annularis (MPI = 5.8%), the An. hyrcanus group (MPI = 0.48%), An. kochi (MPI = 1.28%), the An. philippinensis-nivipes complex (MPI = 0.94%), and An. vagus (MPI = 3.87%), are important vectors in the foothills of Assam.