Deep-Brain Stimulation for Basal Ganglia Disorders.
Deep-Brain Stimulation for Basal Ganglia Disorders.
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DOI：
10.1016/j.baga.2011.05.001
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发表时间：
2011-07-01
期刊：
影响因子：
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通讯作者：
Delong, Mahlon R
中科院分区：
文献类型：
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作者：
Wichmann, Thomas;Delong, Mahlon R
认识到用于治疗运动障碍和基底神经节起源的精神疾病的药物具有显著的缺点，以及对大脑功能组织的理解的进步，已经导致功能性神经外科的复兴，特别是脑深部电刺激（DBS）的使用。运动障碍现在通常用基底神经节输出核的“运动”部分的DBS治疗，特别是丘脑底核和苍白球内段。这些程序非常有效，通常安全。DBS的使用也正在探索在神经精神疾病的治疗中，靶向'边缘'基底神经节-丘脑皮质回路。这些程序的结果也令人鼓舞，但在这一新兴领域仍有许多问题没有得到解答。这篇综述总结了使用DBS治疗神经系统和神经精神疾病的科学原理和实践方面。
The realization that medications used to treat movement disorders and psychiatric conditions of basal ganglia origin have significant shortcomings, as well as advances in the understanding of the functional organization of the brain, has led to a renaissance in functional neurosurgery, and particularly the use of deep brain stimulation (DBS). Movement disorders are now routinely being treated with DBS of ‘motor’ portions of the basal ganglia output nuclei, specifically the subthalamic nucleus and the internal pallidal segment. These procedures are highly effective and generally safe. Use of DBS is also being explored in the treatment of neuropsychiatric disorders, with targeting of the ‘limbic’ basal ganglia-thalamocortical circuitry. The results of these procedures are also encouraging, but many unanswered questions remain in this emerging field. This review summarizes the scientific rationale and practical aspects of using DBS for neurologic and neuropsychiatric disorders.