A sulfonamide based glucose-responsive hydrogel with covalently immobilized glucose oxidase and catalase
A sulfonamide based glucose-responsive hydrogel with covalently immobilized glucose oxidase and catalase
复制标题
DOI：
10.1016/s0168-3659(02)00409-1
复制
发表时间：
2003-01-09
影响因子：
10.8
通讯作者：
Bae, YH
中科院分区：
文献类型：
--
作者：
Kang, SI;Bae, YH
一种新的葡萄糖敏感性水凝胶，基于磺酰胺化学与共价结合的葡萄糖氧化酶和过氧化氢酶，合成和测试。pH诱导的凝胶完全溶胀转变发生在pH 6.5 ~ 7.5之间。在等渗磷酸盐缓冲盐水溶液（pH 7.4）中0-300 mg/dl的葡萄糖浓度范围内，凝胶内的pH从pH 7.4变化至7.2。在相同的葡萄糖浓度范围内，凝胶显示出可逆的葡萄糖依赖性溶胀，从12到8没有滞后，以水（g）/聚合物（g）表示。(C)2002 Elsevier Science B. V.保留所有权利。
A new glucose-sensitive hydrogel, based on sulfonamide chemistry with covalently conjugated glucose oxidase and catalase, was synthesized and tested. The pH-induced full swelling transition of the gel occurred in the range of pH 6.5similar to7.5. In a glucose concentration range of 0-300 mg/dl in an isotonic phosphate buffered saline solution (pH 7.4), the pH inside the gel varied from pH 7.4 to 7.2. At the same glucose concentration range, the gel showed reversible glucose dependent swelling without hysteresis from 12 to 8, expressed in water (g)/polymer (g). (C) 2002 Elsevier Science B.V. All rights reserved.