Glucose Metabolism in Cancer: The Warburg Effect and Beyond
Glucose Metabolism in Cancer: The Warburg Effect and Beyond
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DOI：
10.1007/978-3-030-65768-0_1
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Le, Anne
中科院分区：
文献类型：
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作者：
Bose, Sminu;Zhang, Cissy;Le, Anne
奥托瓦尔堡在1924年观察到一个奇特的现象，在不知不觉中为癌症代谢领域奠定了基础。虽然他的同时代人假设肿瘤细胞从蛋白水解和脂解中获得不受控制的复制所需的能量，但瓦尔堡发现它们快速消耗葡萄糖，即使在氧气存在的情况下也将其转化为乳酸[1]。这一发现的重要性，后来被称为瓦尔堡效应，当时没有被更广泛的科学界注意到。癌症代谢领域休眠了近世纪，等待分子生物学和遗传学的进步，这将为新的癌症疗法打开大门[2，3]。
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate even in the presence of oxygen [1]. The significance of this finding, later termed the Warburg effect, went unnoticed by the broader scientific community at that time. The field of cancer metabolism lay dormant for almost a century awaiting advances in molecular biology and genetics, which would later open the doors to new cancer therapies [2, 3].