The role of cytokines in the pathophysiology of suicidal behavior.
The role of cytokines in the pathophysiology of suicidal behavior.
复制标题
DOI：
10.1016/j.psyneuen.2015.10.008
复制
发表时间：
2016-01
影响因子：
3.7
通讯作者：
Sublette ME
中科院分区：
文献类型：
--
作者：
Ganança L;Oquendo MA;Tyrka AR;Cisneros-Trujillo S;Mann JJ;Sublette ME
免疫失调与抑郁症和其他精神疾病有关。免疫失调如何影响自杀行为的风险尚不清楚。我们回顾了与自杀意念、自杀行为和自杀相关的细胞因子的科学文献，并调查了与细胞因子水平相关的临床和神经生物学因素，这些因素可能调节炎症对自杀风险的影响。我们检索了PubMed、Embase、Scopus和PsycINFO，以查找1980年至2015年2月发表的相关研究。如果论文是用英语写的，并且重点关注自杀行为患者的细胞因子测量，则将其纳入。文献检索获得了22项关于细胞因子与自杀意念、自杀未遂或自杀完成的研究。最一致的发现是白细胞介素（IL）-6升高，14项研究中有8项在CSF、血液和死后大脑中发现。在一项研究中，CSF中的IL-6也被发现在暴力自杀者中高于非暴力自杀者，并与未来的自杀完成相关。在2项自杀未遂者研究中观察到低血浆IL-2，而肿瘤坏死因子（TNF）-α、干扰素（IFN）-γ、转化生长因子（TGF）-β、IL-4和可溶性IL-2受体的结果存在差异。鉴于异质性细胞因子发现所表明的复杂性，自杀行为中炎症的推定介质和调节剂值得进一步研究。IL-6升高是最强有力的细胞因子发现，与自杀意念和非致命性自杀企图和自杀相关。未来的研究应该评估高IL-6的预测价值，考虑这可能如何改变脑功能以影响自杀行为，并探索降低IL-6对自杀风险的潜在有益影响。
Immune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects of inflammation on suicide risk. We searched PubMed, Embase, Scopus and PsycINFO for relevant studies published from 1980 through February, 2015. Papers were included if they were written in English and focused on cytokine measurements in patients with suicidal behaviors. The literature search yielded 22 studies concerning cytokines and suicidal ideation, suicide attempts or suicide completion. The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain. In one study, IL-6 in CSF was also found to be higher in violent than nonviolent attempters and to correlate with future suicide completion. Low plasma IL-2 was observed in 2 studies of suicide attempters, while divergent results were seen for tumor necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, IL-4, and soluble Il-2 receptors. Given the complexity suggested by the heterogenous cytokine findings, putative mediators and moderators of inflammation on suicidal behavior merit further study. Elevated IL-6 was the most robust cytokine finding, associated with suicidal ideation and both nonfatal suicide attempts and suicides. Future studies should evaluate the predictive value of high IL-6, consider how this may alter brain function to impact suicidal behavior, and explore the potential beneficial effects of reducing IL-6 on suicide risk.