NG2 proteoglycan expression in mouse skin: Altered postnatal skin development in the NG2 null mouse
NG2 proteoglycan expression in mouse skin: Altered postnatal skin development in the NG2 null mouse
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DOI：
10.1369/jhc.7a7349.2007
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发表时间：
2008-03-01
影响因子：
3.2
通讯作者：
Stallcup, William B.
中科院分区：
文献类型：
--
作者：
Kadoya, Kuniko;Fukushi, Jun-ichi;Stallcup, William B.
在出生后早期小鼠皮肤中，NG2蛋白多糖在皮下、真皮层、毛囊外根鞘和表皮基底角化细胞层表达。随着进一步发育，NG2在毛囊膨出区域的干细胞中最显著地表达，在成人皮肤中也观察到这一点。在成人毛发周期的休止期和生长期，在真皮乳头和毛囊外根鞘的干细胞群中也发现了NG2。消融NG2可引起新生儿皮肤表皮和皮下层的改变。与野生型相比，NG2无源表皮由于作为该层干细胞群的基底角质形成细胞的增殖减少而不能达到其全厚度。由于脂肪细胞数量不足，NG2缺失皮肤的皮下增厚也会延迟。
In early postnatal mouse skin, the NG2 proteoglycan is expressed in the subcutis, the dermis, the outer root sheath of hair follicles, and the basal keratinocyte layer of the epidermis. With further development, NG2 is most prominently expressed by stem cells in the hair follicle bulge region, as also observed in adult human skin. During telogen and anagen phases of the adult hair cycle, NG2 is also found in stem cell populations that reside in dermal papillae and the outer root sheaths of hair follicles. Ablation of NG2 produces alterations in both the epidermis and subcutis layers of neonatal skin. Compared with wild type, the NG2 null epidermis does not achieve its full thickness due to reduced proliferation of basal keratinocytes that serve as the stem cell population in this layer. Thickening of the subcutis is also delayed in NG2 null skin due to deficiencies in the adipocyte population.