Biotransformation of trivalent and pentavalent inorganic arsenic in mice and rats.
Biotransformation of trivalent and pentavalent inorganic arsenic in mice and rats.
复制标题
三价和五价无机砷在小鼠和大鼠中的生物转化。
DOI：
10.1016/0013-9351(81)90030-x
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发表时间：
1981
影响因子：
8.3
通讯作者：
Marie Vahter
中科院分区：
文献类型：
--
作者：
Marie Vahter
在小鼠暴露于~（74）As标记的三价或五价无机砷后，尿中主要代谢产物为二甲基胂酸。As（III）的甲基化程度高于As（V），但引起更高的全身保留。消除，因此，似乎是较少依赖于甲基化后，暴露于As（V）比暴露于As（III）。低剂量的As（III）被甲基化到一定程度（约80%的剂量），其保留率与As（V）相当。对于两种化合价形式，保留随剂量增加而增加，与甲基化的降低大致平行（以剂量的百分比计）。砷在大鼠体内的滞留量约为小鼠的20倍，在体外，大鼠和小鼠血液中砷与红细胞的结合量相似，但As（III）比As（V）高得多。甲基化，然而，在大鼠中低得多，这可能是一个原因，在大鼠中的砷保留极高的可能性进行了讨论。
In mice exposed to74As-labeled trivalent or pentavalent inorganic arsenic, dimethylarsinic acid was found to be the major urinary metabolite. As(III) was methylated to a greater extent than As(V) but caused higher whole-body retention. Elimination, thus seems to be less dependent on methylation following exposure to As(V) than following exposure to As(III). Low doses of As(III) were methylated to such an extent (about 80% of the dose) that the retention was comparable to that of As(V). For both valence forms, retention increased with increasing dose, approximately parallel to a decrease in the methylation (in percentage of the dose). Whole-body retention of arsenic was about 20 times higher in rats than in mice.In vitrobinding of arsenic to erythrocytes was similar in blood from rats and mice though considerably higher for As(III) than for As(V). Methylation was, however, much lower in the rats and the possibility that this might be one reason for the extremely high retention of arsenic in the rat is discussed.